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Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines

Berberine (BBR) as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic activities. However, it is unknown if BBR can be applied without abrogating the efforts of vaccination. Here we show that priming of CD8...

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Detalles Bibliográficos
Autores principales: Li, Mingyan, Wang, Yaling, Zhang, Lingzhi, Gao, Changxing, Li, Jing J., Jiang, Jiandong, Zhu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213802/
https://www.ncbi.nlm.nih.gov/pubmed/37250162
http://dx.doi.org/10.1016/j.apsb.2023.02.017
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author Li, Mingyan
Wang, Yaling
Zhang, Lingzhi
Gao, Changxing
Li, Jing J.
Jiang, Jiandong
Zhu, Qing
author_facet Li, Mingyan
Wang, Yaling
Zhang, Lingzhi
Gao, Changxing
Li, Jing J.
Jiang, Jiandong
Zhu, Qing
author_sort Li, Mingyan
collection PubMed
description Berberine (BBR) as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic activities. However, it is unknown if BBR can be applied without abrogating the efforts of vaccination. Here we show that priming of CD8(+) T cells in the presence of BBR lead to improved central memory formation (Tcm) with substantially reduced effector proliferation, primarily orchestrated through activation of AMPK and Stat5. Tcm derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to naïve recipients. Vaccination of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy, suggesting appreciable benefits from using BBR in vaccination. Thus, our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory effects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties.
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spelling pubmed-102138022023-05-27 Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines Li, Mingyan Wang, Yaling Zhang, Lingzhi Gao, Changxing Li, Jing J. Jiang, Jiandong Zhu, Qing Acta Pharm Sin B Short Communication Berberine (BBR) as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic activities. However, it is unknown if BBR can be applied without abrogating the efforts of vaccination. Here we show that priming of CD8(+) T cells in the presence of BBR lead to improved central memory formation (Tcm) with substantially reduced effector proliferation, primarily orchestrated through activation of AMPK and Stat5. Tcm derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to naïve recipients. Vaccination of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy, suggesting appreciable benefits from using BBR in vaccination. Thus, our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory effects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties. Elsevier 2023-05 2023-02-28 /pmc/articles/PMC10213802/ /pubmed/37250162 http://dx.doi.org/10.1016/j.apsb.2023.02.017 Text en © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Li, Mingyan
Wang, Yaling
Zhang, Lingzhi
Gao, Changxing
Li, Jing J.
Jiang, Jiandong
Zhu, Qing
Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title_full Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title_fullStr Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title_full_unstemmed Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title_short Berberine improves central memory formation of CD8(+) T cells: Implications for design of natural product-based vaccines
title_sort berberine improves central memory formation of cd8(+) t cells: implications for design of natural product-based vaccines
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213802/
https://www.ncbi.nlm.nih.gov/pubmed/37250162
http://dx.doi.org/10.1016/j.apsb.2023.02.017
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