From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Tintelnot et al.(1) identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy...

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Detalles Bibliográficos
Autores principales: Seo, Y. David, Wargo, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213830/
https://www.ncbi.nlm.nih.gov/pubmed/37196631
http://dx.doi.org/10.1016/j.xcrm.2023.101039
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author Seo, Y. David
Wargo, Jennifer A.
author_facet Seo, Y. David
Wargo, Jennifer A.
author_sort Seo, Y. David
collection PubMed
description Tintelnot et al.(1) identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.
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spelling pubmed-102138302023-05-27 From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer Seo, Y. David Wargo, Jennifer A. Cell Rep Med Spotlight Tintelnot et al.(1) identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization. Elsevier 2023-05-16 /pmc/articles/PMC10213830/ /pubmed/37196631 http://dx.doi.org/10.1016/j.xcrm.2023.101039 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Seo, Y. David
Wargo, Jennifer A.
From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title_full From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title_fullStr From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title_full_unstemmed From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title_short From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
title_sort from bugs to drugs: bacterial 3-iaa enhances efficacy of chemotherapy in pancreatic cancer
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213830/
https://www.ncbi.nlm.nih.gov/pubmed/37196631
http://dx.doi.org/10.1016/j.xcrm.2023.101039
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