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Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo

OBJECTIVE: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. METHODS: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexi...

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Autores principales: Tolentino Limeira, Rebecca Rhuanny, Lima Arrais Ribeiro, Isabella, Ferreti Bonan, Paulo Rogério, da Nóbrega Alves, Danielle, dos Santos Ferreira, Elba, Vieira Lopes da Costa, Tereza Karla, Weege Nonaka, Cassiano Francisco, Dantas de Medeiros, Ana Claúdia, Barbosa de Sousa, Frederico, Gondim Valença, Ana Maria, Dias de Castro, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213868/
https://www.ncbi.nlm.nih.gov/pubmed/37251722
http://dx.doi.org/10.1016/j.sdentj.2023.03.014
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author Tolentino Limeira, Rebecca Rhuanny
Lima Arrais Ribeiro, Isabella
Ferreti Bonan, Paulo Rogério
da Nóbrega Alves, Danielle
dos Santos Ferreira, Elba
Vieira Lopes da Costa, Tereza Karla
Weege Nonaka, Cassiano Francisco
Dantas de Medeiros, Ana Claúdia
Barbosa de Sousa, Frederico
Gondim Valença, Ana Maria
Dias de Castro, Ricardo
author_facet Tolentino Limeira, Rebecca Rhuanny
Lima Arrais Ribeiro, Isabella
Ferreti Bonan, Paulo Rogério
da Nóbrega Alves, Danielle
dos Santos Ferreira, Elba
Vieira Lopes da Costa, Tereza Karla
Weege Nonaka, Cassiano Francisco
Dantas de Medeiros, Ana Claúdia
Barbosa de Sousa, Frederico
Gondim Valença, Ana Maria
Dias de Castro, Ricardo
author_sort Tolentino Limeira, Rebecca Rhuanny
collection PubMed
description OBJECTIVE: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. METHODS: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8, G3). The animals were submitted to clinical and histological analysis of the lesion using mucosal fragments. The animals' food consumption during treatment was also evaluated. RESULTS: Clinical improvement (p < 0.05) was observed in the groups treated with the multidrug solution and 0.12% chlorhexidine digluconate. In G2 and G3, there was a prevalence of reepithelialization covering <50% of the lesion. Evaluation of the inflammatory infiltrate indicated that the G1 treatment permitted an intense inflammatory response in all animals, yet this evaluation parameter was moderate in groups G2 and G3. The G3 group (p < 0.05) presented higher food consumption than the other groups. CONCLUSIONS: The multidrug solution improved the clinical and histological parameters of the chemotherapy-induced oral mucositis, as well as promoted an increase in food intake.
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spelling pubmed-102138682023-05-27 Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo Tolentino Limeira, Rebecca Rhuanny Lima Arrais Ribeiro, Isabella Ferreti Bonan, Paulo Rogério da Nóbrega Alves, Danielle dos Santos Ferreira, Elba Vieira Lopes da Costa, Tereza Karla Weege Nonaka, Cassiano Francisco Dantas de Medeiros, Ana Claúdia Barbosa de Sousa, Frederico Gondim Valença, Ana Maria Dias de Castro, Ricardo Saudi Dent J Original Article OBJECTIVE: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. METHODS: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8, G3). The animals were submitted to clinical and histological analysis of the lesion using mucosal fragments. The animals' food consumption during treatment was also evaluated. RESULTS: Clinical improvement (p < 0.05) was observed in the groups treated with the multidrug solution and 0.12% chlorhexidine digluconate. In G2 and G3, there was a prevalence of reepithelialization covering <50% of the lesion. Evaluation of the inflammatory infiltrate indicated that the G1 treatment permitted an intense inflammatory response in all animals, yet this evaluation parameter was moderate in groups G2 and G3. The G3 group (p < 0.05) presented higher food consumption than the other groups. CONCLUSIONS: The multidrug solution improved the clinical and histological parameters of the chemotherapy-induced oral mucositis, as well as promoted an increase in food intake. Elsevier 2023-05 2023-04-05 /pmc/articles/PMC10213868/ /pubmed/37251722 http://dx.doi.org/10.1016/j.sdentj.2023.03.014 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Tolentino Limeira, Rebecca Rhuanny
Lima Arrais Ribeiro, Isabella
Ferreti Bonan, Paulo Rogério
da Nóbrega Alves, Danielle
dos Santos Ferreira, Elba
Vieira Lopes da Costa, Tereza Karla
Weege Nonaka, Cassiano Francisco
Dantas de Medeiros, Ana Claúdia
Barbosa de Sousa, Frederico
Gondim Valença, Ana Maria
Dias de Castro, Ricardo
Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title_full Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title_fullStr Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title_full_unstemmed Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title_short Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
title_sort effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213868/
https://www.ncbi.nlm.nih.gov/pubmed/37251722
http://dx.doi.org/10.1016/j.sdentj.2023.03.014
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