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Gallbladder cancer: current and future treatment options

Surgery remains the preferred treatment option for early-stage gallbladder cancer (GBC). According to the anatomical position of the primary tumor, accurate preoperative stage and strict control of surgical indications, appropriate surgical strategies are selected to achieve the optimal surgical eff...

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Autores principales: Zhou, Yanzhao, Yuan, Kun, Yang, Yi, Ji, Zemin, Zhou, Dezheng, Ouyang, Jingzhong, Wang, Zhengzheng, Wang, Fuqiang, Liu, Chang, Li, Qingjun, Zhang, Qi, Li, Qiang, Shan, Xiao, Zhou, Jinxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213899/
https://www.ncbi.nlm.nih.gov/pubmed/37251319
http://dx.doi.org/10.3389/fphar.2023.1183619
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author Zhou, Yanzhao
Yuan, Kun
Yang, Yi
Ji, Zemin
Zhou, Dezheng
Ouyang, Jingzhong
Wang, Zhengzheng
Wang, Fuqiang
Liu, Chang
Li, Qingjun
Zhang, Qi
Li, Qiang
Shan, Xiao
Zhou, Jinxue
author_facet Zhou, Yanzhao
Yuan, Kun
Yang, Yi
Ji, Zemin
Zhou, Dezheng
Ouyang, Jingzhong
Wang, Zhengzheng
Wang, Fuqiang
Liu, Chang
Li, Qingjun
Zhang, Qi
Li, Qiang
Shan, Xiao
Zhou, Jinxue
author_sort Zhou, Yanzhao
collection PubMed
description Surgery remains the preferred treatment option for early-stage gallbladder cancer (GBC). According to the anatomical position of the primary tumor, accurate preoperative stage and strict control of surgical indications, appropriate surgical strategies are selected to achieve the optimal surgical effect. However, most patients have already been at the locally advanced stage or the tumor has metastasized at the initial diagnosis. The postoperative recurrence rate and 5-year survival rate remain unsatisfactory even after radical resection for gallbladder cancer. Hence, there is an urgent need for more treatment options, such as neoadjuvant therapy, postoperative adjuvant therapy and first-line and second-line treatments of local progression and metastasis, in the whole-course treatment management of gallbladder cancer patients. In recent years, the application of molecular targeted drugs and immunotherapy has brought greater hope and broader prospects for the treatment of gallbladder cancer, but their effects in improving the prognosis of patients still lack sufficient evidence-based medicine evidence, so many problems should be addressed by further research. Based on the latest progress in gallbladder cancer research, this review systematically analyzes the treatment trends of gallbladder cancer.
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spelling pubmed-102138992023-05-27 Gallbladder cancer: current and future treatment options Zhou, Yanzhao Yuan, Kun Yang, Yi Ji, Zemin Zhou, Dezheng Ouyang, Jingzhong Wang, Zhengzheng Wang, Fuqiang Liu, Chang Li, Qingjun Zhang, Qi Li, Qiang Shan, Xiao Zhou, Jinxue Front Pharmacol Pharmacology Surgery remains the preferred treatment option for early-stage gallbladder cancer (GBC). According to the anatomical position of the primary tumor, accurate preoperative stage and strict control of surgical indications, appropriate surgical strategies are selected to achieve the optimal surgical effect. However, most patients have already been at the locally advanced stage or the tumor has metastasized at the initial diagnosis. The postoperative recurrence rate and 5-year survival rate remain unsatisfactory even after radical resection for gallbladder cancer. Hence, there is an urgent need for more treatment options, such as neoadjuvant therapy, postoperative adjuvant therapy and first-line and second-line treatments of local progression and metastasis, in the whole-course treatment management of gallbladder cancer patients. In recent years, the application of molecular targeted drugs and immunotherapy has brought greater hope and broader prospects for the treatment of gallbladder cancer, but their effects in improving the prognosis of patients still lack sufficient evidence-based medicine evidence, so many problems should be addressed by further research. Based on the latest progress in gallbladder cancer research, this review systematically analyzes the treatment trends of gallbladder cancer. Frontiers Media S.A. 2023-05-11 /pmc/articles/PMC10213899/ /pubmed/37251319 http://dx.doi.org/10.3389/fphar.2023.1183619 Text en Copyright © 2023 Zhou, Yuan, Yang, Ji, Zhou, Ouyang, Wang, Wang, Liu, Li, Zhang, Li, Shan and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Yanzhao
Yuan, Kun
Yang, Yi
Ji, Zemin
Zhou, Dezheng
Ouyang, Jingzhong
Wang, Zhengzheng
Wang, Fuqiang
Liu, Chang
Li, Qingjun
Zhang, Qi
Li, Qiang
Shan, Xiao
Zhou, Jinxue
Gallbladder cancer: current and future treatment options
title Gallbladder cancer: current and future treatment options
title_full Gallbladder cancer: current and future treatment options
title_fullStr Gallbladder cancer: current and future treatment options
title_full_unstemmed Gallbladder cancer: current and future treatment options
title_short Gallbladder cancer: current and future treatment options
title_sort gallbladder cancer: current and future treatment options
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213899/
https://www.ncbi.nlm.nih.gov/pubmed/37251319
http://dx.doi.org/10.3389/fphar.2023.1183619
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