Air pollution, EGFR mutation, and cancer initiation

Swanton et al.(1) find that PM(2.5) exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM(2.5) increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to i...

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Detalles Bibliográficos
Autores principales: Han, Si-Chong, Wang, Gui-Zhen, Zhou, Guang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213952/
https://www.ncbi.nlm.nih.gov/pubmed/37196632
http://dx.doi.org/10.1016/j.xcrm.2023.101046
Descripción
Sumario:Swanton et al.(1) find that PM(2.5) exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM(2.5) increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

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