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Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide inhibitor of PD-1 signal pathway (AUNP-12), which...

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Detalles Bibliográficos
Autores principales:	Hu, Chuan, Song, Yujun, Zhang, Yiwei, He, Siqin, Liu, Xueying, Yang, Xiaotong, Gong, Tao, Huang, Yuan, Gao, Huile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213972/ https://www.ncbi.nlm.nih.gov/pubmed/37250156 http://dx.doi.org/10.1016/j.apsb.2023.02.009

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