UHRF1/DNMT1–MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variants (PRSS3-SVs; PRSS3-V1–V4),...

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Detalles Bibliográficos
Autores principales: Lin, Shuye, Xu, Hanli, Qin, Lin, Pang, Mengdi, Wang, Ziyu, Gu, Meng, Zhang, Lishu, Zhao, Cong, Hao, Xuefeng, Zhang, Zhiyun, Ding, Weimin, Ren, Jianke, Huang, Jiaqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213989/
https://www.ncbi.nlm.nih.gov/pubmed/37250150
http://dx.doi.org/10.1016/j.apsb.2023.02.015

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