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Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis

The present meta-analysis was conducted to determine the efficacy of hydroxyurea in patients with transfusion dependent major β-thalassemia. The present meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses of Observat...

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Autores principales: Hatamleh, Modather I, Chenna, Venkata Sai Harshabhargav, Contractor, Hazel, Krishna Mohan, Gautham Varun, Tirumandyam, Gayathri, Dammas, Nada, Khan, Muhammad Waqas, Hirani, Shamsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213992/
https://www.ncbi.nlm.nih.gov/pubmed/37252463
http://dx.doi.org/10.7759/cureus.38135
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author Hatamleh, Modather I
Chenna, Venkata Sai Harshabhargav
Contractor, Hazel
Krishna Mohan, Gautham Varun
Tirumandyam, Gayathri
Dammas, Nada
Khan, Muhammad Waqas
Hirani, Shamsha
author_facet Hatamleh, Modather I
Chenna, Venkata Sai Harshabhargav
Contractor, Hazel
Krishna Mohan, Gautham Varun
Tirumandyam, Gayathri
Dammas, Nada
Khan, Muhammad Waqas
Hirani, Shamsha
author_sort Hatamleh, Modather I
collection PubMed
description The present meta-analysis was conducted to determine the efficacy of hydroxyurea in patients with transfusion dependent major β-thalassemia. The present meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. A systematic search was carried out to evaluate the efficacy of hydroxyurea in patients with transfusion-dependent B-thalassaemia using electronic databases, including MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE. The keywords used to search for relevant studies included “hydroxyurea”, “thalassemia”, “transfusion-dependent”, and “efficacy”. Outcomes assessed in the present meta-analysis included transfusion in one year and intervals between transfusions (in days). Other outcomes assessed in the present meta-analysis were fetal hemoglobin (%), hemoglobin (%), and ferritin levels (ng/dl). Total of five studies were included in the analysis enrolling 294 patients with major B-thalassemia. The pooled analysis reported that the mean interval between transfusions was significantly higher in patients receiving hydroxyurea compared to those not receiving hydroxyurea (mean deviation {MD}: 10.07, 95% CI: 2.16, 17.99). Hemoglobin was significantly higher in patients receiving hydroxyurea compared to its counterparts (MD: 1.71, 95% CI: 0.84, 2.57). Patients receiving hydroxyurea had significantly lower ferritin levels compared to those not receiving hydroxyurea (MD: -299.65, 95% CI: -518.35, -80.96). These findings suggest that hydroxyurea may be a promising and cost-effective alternative to blood transfusions and iron chelation therapies for beta-thalassemia patients. However, the authors noted that further randomized controlled trials are needed to validate these findings and to determine the optimal dosages and treatment regimens for hydroxyurea in this patient population.
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spelling pubmed-102139922023-05-27 Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis Hatamleh, Modather I Chenna, Venkata Sai Harshabhargav Contractor, Hazel Krishna Mohan, Gautham Varun Tirumandyam, Gayathri Dammas, Nada Khan, Muhammad Waqas Hirani, Shamsha Cureus Internal Medicine The present meta-analysis was conducted to determine the efficacy of hydroxyurea in patients with transfusion dependent major β-thalassemia. The present meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. A systematic search was carried out to evaluate the efficacy of hydroxyurea in patients with transfusion-dependent B-thalassaemia using electronic databases, including MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE. The keywords used to search for relevant studies included “hydroxyurea”, “thalassemia”, “transfusion-dependent”, and “efficacy”. Outcomes assessed in the present meta-analysis included transfusion in one year and intervals between transfusions (in days). Other outcomes assessed in the present meta-analysis were fetal hemoglobin (%), hemoglobin (%), and ferritin levels (ng/dl). Total of five studies were included in the analysis enrolling 294 patients with major B-thalassemia. The pooled analysis reported that the mean interval between transfusions was significantly higher in patients receiving hydroxyurea compared to those not receiving hydroxyurea (mean deviation {MD}: 10.07, 95% CI: 2.16, 17.99). Hemoglobin was significantly higher in patients receiving hydroxyurea compared to its counterparts (MD: 1.71, 95% CI: 0.84, 2.57). Patients receiving hydroxyurea had significantly lower ferritin levels compared to those not receiving hydroxyurea (MD: -299.65, 95% CI: -518.35, -80.96). These findings suggest that hydroxyurea may be a promising and cost-effective alternative to blood transfusions and iron chelation therapies for beta-thalassemia patients. However, the authors noted that further randomized controlled trials are needed to validate these findings and to determine the optimal dosages and treatment regimens for hydroxyurea in this patient population. Cureus 2023-04-26 /pmc/articles/PMC10213992/ /pubmed/37252463 http://dx.doi.org/10.7759/cureus.38135 Text en Copyright © 2023, Hatamleh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Hatamleh, Modather I
Chenna, Venkata Sai Harshabhargav
Contractor, Hazel
Krishna Mohan, Gautham Varun
Tirumandyam, Gayathri
Dammas, Nada
Khan, Muhammad Waqas
Hirani, Shamsha
Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title_full Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title_fullStr Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title_full_unstemmed Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title_short Efficacy of Hydroxyurea in Transfusion-Dependent Major β-Thalassemia Patients: A Meta-Analysis
title_sort efficacy of hydroxyurea in transfusion-dependent major β-thalassemia patients: a meta-analysis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213992/
https://www.ncbi.nlm.nih.gov/pubmed/37252463
http://dx.doi.org/10.7759/cureus.38135
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