Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model

Brain insulin signaling controls peripheral energy metabolism and plays a key role in the regulation of mood and cognition. Epidemiological studies have indicated a strong connection between type 2 diabetes (T2D) and neurodegenerative disorders, especially Alzheimer’s disease (AD), linked via dysreg...

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Detalles Bibliográficos
Autores principales: Chen, Wenqiang, Huang, Qian, Lazdon, Ekaterina Katie, Gomes, Antonio, Wong, Marisa, Stephens, Emily, Royal, Tabitha Grace, Frenkel, Dan, Cai, Weikang, Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214134/
https://www.ncbi.nlm.nih.gov/pubmed/37186836
http://dx.doi.org/10.1073/pnas.2220684120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214134/
https://www.ncbi.nlm.nih.gov/pubmed/37186836
http://dx.doi.org/10.1073/pnas.2220684120

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