IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe Isoform peptides from RNA splicing for Immunotherapy target Screening (IRIS), a computational platform capable of discovering AS-derived tumor antig...

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Detalles Bibliográficos
Autores principales: Pan, Yang, Phillips, John W., Zhang, Beatrice D., Noguchi, Miyako, Kutschera, Eric, McLaughlin, Jami, Nesterenko, Pavlo A., Mao, Zhiyuan, Bangayan, Nathanael J., Wang, Robert, Tran, Wendy, Yang, Harry T., Wang, Yuanyuan, Xu, Yang, Obusan, Matthew B., Cheng, Donghui, Lee, Alex H., Kadash-Edmondson, Kathryn E., Champhekar, Ameya, Puig-Saus, Cristina, Ribas, Antoni, Prins, Robert M., Seet, Christopher S., Crooks, Gay M., Witte, Owen N., Xing, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214192/
https://www.ncbi.nlm.nih.gov/pubmed/37192158
http://dx.doi.org/10.1073/pnas.2221116120

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