Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)

Vesicle Fusion In article number 2206823, using the bottom‐up synthetic reconstitution, electron microscopy, and in‐vivo amperometry, Yongsoo Park and co‐workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotag...

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Detalles Bibliográficos
Autores principales: Ali Moussa, Houda Yasmine, Shin, Kyung Chul, Ponraj, Janarthanan, Kim, Soo Jin, Ryu, Je‐Kyung, Mansour, Said, Park, Yongsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214220/
http://dx.doi.org/10.1002/advs.202370092
Descripción
Sumario:Vesicle Fusion In article number 2206823, using the bottom‐up synthetic reconstitution, electron microscopy, and in‐vivo amperometry, Yongsoo Park and co‐workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotagmin‐1 insertion, thereby lowering the energy barrier for Ca(2+)‐dependent fusion to occur. [Image: see text]

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