Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)

Vesicle Fusion In article number 2206823, using the bottom‐up synthetic reconstitution, electron microscopy, and in‐vivo amperometry, Yongsoo Park and co‐workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotag...

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Autores principales: Ali Moussa, Houda Yasmine, Shin, Kyung Chul, Ponraj, Janarthanan, Kim, Soo Jin, Ryu, Je‐Kyung, Mansour, Said, Park, Yongsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214220/
http://dx.doi.org/10.1002/advs.202370092
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author Ali Moussa, Houda Yasmine
Shin, Kyung Chul
Ponraj, Janarthanan
Kim, Soo Jin
Ryu, Je‐Kyung
Mansour, Said
Park, Yongsoo
author_facet Ali Moussa, Houda Yasmine
Shin, Kyung Chul
Ponraj, Janarthanan
Kim, Soo Jin
Ryu, Je‐Kyung
Mansour, Said
Park, Yongsoo
author_sort Ali Moussa, Houda Yasmine
collection PubMed
description Vesicle Fusion In article number 2206823, using the bottom‐up synthetic reconstitution, electron microscopy, and in‐vivo amperometry, Yongsoo Park and co‐workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotagmin‐1 insertion, thereby lowering the energy barrier for Ca(2+)‐dependent fusion to occur. [Image: see text]
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spelling pubmed-102142202023-05-27 Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023) Ali Moussa, Houda Yasmine Shin, Kyung Chul Ponraj, Janarthanan Kim, Soo Jin Ryu, Je‐Kyung Mansour, Said Park, Yongsoo Adv Sci (Weinh) Frontispiece Vesicle Fusion In article number 2206823, using the bottom‐up synthetic reconstitution, electron microscopy, and in‐vivo amperometry, Yongsoo Park and co‐workers show novel mechanisms of vesicle fusion triggered by calcium ions. Cholesterol stabilizes the local membrane bending induced by synaptotagmin‐1 insertion, thereby lowering the energy barrier for Ca(2+)‐dependent fusion to occur. [Image: see text] John Wiley and Sons Inc. 2023-05-26 /pmc/articles/PMC10214220/ http://dx.doi.org/10.1002/advs.202370092 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Ali Moussa, Houda Yasmine
Shin, Kyung Chul
Ponraj, Janarthanan
Kim, Soo Jin
Ryu, Je‐Kyung
Mansour, Said
Park, Yongsoo
Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title_full Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title_fullStr Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title_full_unstemmed Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title_short Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending (Adv. Sci. 15/2023)
title_sort requirement of cholesterol for calcium‐dependent vesicle fusion by strengthening synaptotagmin‐1‐induced membrane bending (adv. sci. 15/2023)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214220/
http://dx.doi.org/10.1002/advs.202370092
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