Central precocious puberty in Prader-Willi syndrome: a narrative review

Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability...

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Autores principales: Nicoară, Delia-Maria, Scutca, Alexandra-Cristina, Mang, Niculina, Juganaru, Iulius, Munteanu, Andrei-Ioan, Vitan, Luiza, Mărginean, Otilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214499/
https://www.ncbi.nlm.nih.gov/pubmed/37251677
http://dx.doi.org/10.3389/fendo.2023.1150323
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author Nicoară, Delia-Maria
Scutca, Alexandra-Cristina
Mang, Niculina
Juganaru, Iulius
Munteanu, Andrei-Ioan
Vitan, Luiza
Mărginean, Otilia
author_facet Nicoară, Delia-Maria
Scutca, Alexandra-Cristina
Mang, Niculina
Juganaru, Iulius
Munteanu, Andrei-Ioan
Vitan, Luiza
Mărginean, Otilia
author_sort Nicoară, Delia-Maria
collection PubMed
description Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability regarding sexual maturation, with precocious puberty occurring in rare cases. Our aim is to elaborate a thorough review of Prader-Willi patients with central precocious puberty, in order to raise awareness of such cases and to enhance our knowledge regarding the diagnosis and prompt treatment of this particular PWS patients.
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spelling pubmed-102144992023-05-27 Central precocious puberty in Prader-Willi syndrome: a narrative review Nicoară, Delia-Maria Scutca, Alexandra-Cristina Mang, Niculina Juganaru, Iulius Munteanu, Andrei-Ioan Vitan, Luiza Mărginean, Otilia Front Endocrinol (Lausanne) Endocrinology Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability regarding sexual maturation, with precocious puberty occurring in rare cases. Our aim is to elaborate a thorough review of Prader-Willi patients with central precocious puberty, in order to raise awareness of such cases and to enhance our knowledge regarding the diagnosis and prompt treatment of this particular PWS patients. Frontiers Media S.A. 2023-05-08 /pmc/articles/PMC10214499/ /pubmed/37251677 http://dx.doi.org/10.3389/fendo.2023.1150323 Text en Copyright © 2023 Nicoară, Scutca, Mang, Juganaru, Munteanu, Vitan and Mărginean https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Nicoară, Delia-Maria
Scutca, Alexandra-Cristina
Mang, Niculina
Juganaru, Iulius
Munteanu, Andrei-Ioan
Vitan, Luiza
Mărginean, Otilia
Central precocious puberty in Prader-Willi syndrome: a narrative review
title Central precocious puberty in Prader-Willi syndrome: a narrative review
title_full Central precocious puberty in Prader-Willi syndrome: a narrative review
title_fullStr Central precocious puberty in Prader-Willi syndrome: a narrative review
title_full_unstemmed Central precocious puberty in Prader-Willi syndrome: a narrative review
title_short Central precocious puberty in Prader-Willi syndrome: a narrative review
title_sort central precocious puberty in prader-willi syndrome: a narrative review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214499/
https://www.ncbi.nlm.nih.gov/pubmed/37251677
http://dx.doi.org/10.3389/fendo.2023.1150323
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