Rational Chemical Design of Molecular Glue Degraders

[Image: see text] Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic modality for eliminating classically undruggable disease-causing proteins through proteasome-mediated degradation. However, we currently lack rational chemical design principles for conv...

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Detalles Bibliográficos
Autores principales: Toriki, Ethan S., Papatzimas, James W., Nishikawa, Kaila, Dovala, Dustin, Frank, Andreas O., Hesse, Matthew J., Dankova, Daniela, Song, Jae-Geun, Bruce-Smythe, Megan, Struble, Heidi, Garcia, Francisco J., Brittain, Scott M., Kile, Andrew C., McGregor, Lynn M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214506/
https://www.ncbi.nlm.nih.gov/pubmed/37252349
http://dx.doi.org/10.1021/acscentsci.2c01317

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