Cargando…

Dihydroxy-Metabolites of Dihomo-γ-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration

[Image: see text] Even after decades of research, the mechanism of neurodegeneration remains understudied, hindering the discovery of effective treatments for neurodegenerative diseases. Recent reports suggest that ferroptosis could be a novel therapeutic target for neurodegenerative diseases. While...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarparast, Morteza, Pourmand, Elham, Hinman, Jennifer, Vonarx, Derek, Reason, Tommy, Zhang, Fan, Paithankar, Shreya, Chen, Bin, Borhan, Babak, Watts, Jennifer L., Alan, Jamie, Lee, Kin Sing Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214511/ https://www.ncbi.nlm.nih.gov/pubmed/37252355 http://dx.doi.org/10.1021/acscentsci.3c00052

Ejemplares similares

Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration
por: Sarparast, Morteza, et al.
Publicado: (2023)

Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans
por: Sarparast, Morteza, et al.
Publicado: (2023)

Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans
por: Deline, Marshall, et al.
Publicado: (2015)

Multiple roles of dihomo-γ-linolenic acid against proliferation diseases
por: Wang, Xiaoping, et al.
Publicado: (2012)

Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis
por: Gallagher, Hayley, et al.
Publicado: (2019)

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration
por: Sarparast, Morteza, et al.
Publicado: (2020)

The Linoleic Acid: Dihomo-γ-Linolenic Acid Ratio (LA:DGLA)—An Emerging Biomarker of Zn Status
por: Knez, Marija, et al.
Publicado: (2017)

Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
por: Hua, Man-Chin, et al.
Publicado: (2021)

Physiological Traits of Dihomo-γ-Linolenic Acid Production of the Engineered Aspergillus oryzae by Comparing Mathematical Models
por: Antimanon, Sompot, et al.
Publicado: (2020)

Dihomo-γ-Linolenic Acid (20:3n-6)—Metabolism, Derivatives, and Potential Significance in Chronic Inflammation
por: Mustonen, Anne-Mari, et al.
Publicado: (2023)

Quantitative Profiling Method for Oxylipins in Neurodegenerative Diseases by Liquid Chromatography Coupled with Tandem Mass Spectrometry
por: Pourmand, Elham, et al.
Publicado: (2023)

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression
por: Xu, Yi, et al.
Publicado: (2018)

Decreased circulating dihomo-gamma-linolenic acid levels are associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure
por: Ouchi, Shohei, et al.
Publicado: (2017)

Dietary patterns related to zinc and polyunsaturated fatty acids intake are associated with serum linoleic/dihomo-γ-linolenic ratio in NHANES males and females
por: Monteiro, Jacqueline Pontes, et al.
Publicado: (2021)

Supplementation of Dihomo-γ-Linolenic Acid for Pollen-Induced Allergic Symptoms in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial
por: Yokoi, Kaori, et al.
Publicado: (2023)

Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes
por: Tsurutani, Yuya, et al.
Publicado: (2018)

Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase
por: Xu, Yi, et al.
Publicado: (2018)

Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction
por: Nilsen, Dennis Winston T., et al.
Publicado: (2021)

Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil׳s cytotoxicity
por: Xu, Yi, et al.
Publicado: (2014)

Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses
por: Ouchi, Shohei, et al.
Publicado: (2017)

Dietary Zinc Deficiency Affects Blood Linoleic Acid: Dihomo-γ-linolenic Acid (LA:DGLA) Ratio; a Sensitive Physiological Marker of Zinc Status in Vivo (Gallus gallus)
por: Reed, Spenser, et al.
Publicado: (2014)

Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA
por: Yang, Xiaoyu, et al.
Publicado: (2018)

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism
por: Xu, Yi, et al.
Publicado: (2018)

Alpha-Linolenic Acid Impedes Cadmium-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration in Mouse Brain
por: Alam, Sayed-Ibrar, et al.
Publicado: (2021)

Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity
por: Aristizabal, Juan C., et al.
Publicado: (2018)

Editorial: Ferroptosis in stroke, neurotrauma and neurodegeneration, volume II
por: Xu, Weilin, et al.
Publicado: (2023)

4-[(2,4-Dihydroxybenzylidene)ammonio]benzenesulfonate trihydrate
por: Yeap, Chin Sing, et al.
Publicado: (2010)

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
por: Abdalkader, Moataz, et al.
Publicado: (2018)

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
por: Ryan, Sean K., et al.
Publicado: (2022)

Influence of linolenic acid in the production of jasmonate
por: Leite, Vera, et al.
Publicado: (2014)

The Effects of Alpha-Linolenic Acid on the Secretory Activity of Astrocytes and β Amyloid-Associated Neurodegeneration in Differentiated SH-SY5Y Cells: Alpha-Linolenic Acid Protects the SH-SY5Y cells against β Amyloid Toxicity
por: Litwiniuk, Anna, et al.
Publicado: (2020)

α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux
por: Li, Guohua, et al.
Publicado: (2020)

Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis
por: Mortensen, Michael S., et al.
Publicado: (2023)

Response to “The Supero-Septum Pedicle Mammaplasty: How Does It Perform?”
por: Hesamirostami, Mohammadhossein, et al.
Publicado: (2021)

Ironing out Neurodegeneration: New Class of Lipids Promotes Ferroptosis in Dopaminergic Neurons
por: Kostenko, Anastasiia, et al.
Publicado: (2023)

Cancer Chemopreventive Ability of Conjugated Linolenic Acids
por: Tanaka, Takuji, et al.
Publicado: (2011)

Alpha-Linolenic Acid: Is It Essential to Cardiovascular Health?
por: Geleijnse, Johanna M., et al.
Publicado: (2010)

Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition
por: Sala-Vila, Aleix, et al.
Publicado: (2022)

Snapshot situation of oxidative degradation of the nervous system, kidney, and adrenal glands biomarkers-neuroprostane and dihomo-isoprostanes-urinary biomarkers from infancy to elderly adults
por: García-Flores, Libia Alejandra, et al.
Publicado: (2017)

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis
por: DeGregorio-Rocasolano, Núria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kuncj5eos4ep7j3pkffhm6rfql