Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules

[Image: see text] Nature has evolved intricate machinery to target and degrade RNA, and some of these molecular mechanisms can be adapted for therapeutic use. Small interfering RNAs and RNase H-inducing oligonucleotides have yielded therapeutic agents against diseases that cannot be tackled using pr...

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Detalles Bibliográficos
Autores principales: Mikutis, Sigitas, Rebelo, Maria, Yankova, Eliza, Gu, Muxin, Tang, Cong, Coelho, Ana R., Yang, Mo, Hazemi, Madoka E., Pires de Miranda, Marta, Eleftheriou, Maria, Robertson, Max, Vassiliou, George S., Adams, David J., Simas, J. Pedro, Corzana, Francisco, Schneekloth, John S., Tzelepis, Konstantinos, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214512/
https://www.ncbi.nlm.nih.gov/pubmed/37252343
http://dx.doi.org/10.1021/acscentsci.3c00015

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