Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3

[Image: see text] Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins. Using a combination of new protein...

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Detalles Bibliográficos
Autores principales: Farnung, Jakob, Muhar, Matthias, Liang, Jin Rui, Tolmachova, Kateryna A., Benoit, Roger M., Corn, Jacob E., Bode, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214526/
https://www.ncbi.nlm.nih.gov/pubmed/37252361
http://dx.doi.org/10.1021/acscentsci.3c00009

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