A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation

Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) and TNF inh...

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Autores principales: Zheng, Guan, Peng, Xiaoshuai, Zhang, Yunhui, Wang, Peng, Xie, Zhongyu, Li, Jinteng, Liu, Wenjie, Ye, Guiwen, Lin, Yucong, Li, Guojian, Liu, Huatao, Zeng, Chenying, Li, Lihua, Wu, Yanfeng, Shen, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214592/
https://www.ncbi.nlm.nih.gov/pubmed/37231465
http://dx.doi.org/10.1186/s12951-023-01906-2
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author Zheng, Guan
Peng, Xiaoshuai
Zhang, Yunhui
Wang, Peng
Xie, Zhongyu
Li, Jinteng
Liu, Wenjie
Ye, Guiwen
Lin, Yucong
Li, Guojian
Liu, Huatao
Zeng, Chenying
Li, Lihua
Wu, Yanfeng
Shen, Huiyong
author_facet Zheng, Guan
Peng, Xiaoshuai
Zhang, Yunhui
Wang, Peng
Xie, Zhongyu
Li, Jinteng
Liu, Wenjie
Ye, Guiwen
Lin, Yucong
Li, Guojian
Liu, Huatao
Zeng, Chenying
Li, Lihua
Wu, Yanfeng
Shen, Huiyong
author_sort Zheng, Guan
collection PubMed
description Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) and TNF inhibitors, are limited by side effects, high costs and unclear inhibitory effects on heterotopic ossification. Herein, we developed manganese ferrite nanoparticles modified by the aptamer CH6 (CH6-MF NPs) that can efficiently scavenge ROS and actively deliver siRNA into hMSCs and osteoblasts in vivo for effective AS treatment. CH6-MF NPs loaded with BMP2 siRNA (CH6-MF-Si NPs) effectively suppressed abnormal osteogenic differentiation under inflammatory conditions in vitro. During their circulation and passive accumulation in inflamed joints in the Zap70(mut) mouse model, CH6-MF-Si NPs attenuated local inflammation and rescued heterotopic ossification in the entheses. Thus, CH6-MF NPs may be an effective inflammation reliever and osteoblast-specific delivery system, and CH6-MF-Si NPs have potential for the dual treatment of chronic inflammation and heterotopic ossification in AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01906-2.
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spelling pubmed-102145922023-05-27 A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation Zheng, Guan Peng, Xiaoshuai Zhang, Yunhui Wang, Peng Xie, Zhongyu Li, Jinteng Liu, Wenjie Ye, Guiwen Lin, Yucong Li, Guojian Liu, Huatao Zeng, Chenying Li, Lihua Wu, Yanfeng Shen, Huiyong J Nanobiotechnology Research Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) and TNF inhibitors, are limited by side effects, high costs and unclear inhibitory effects on heterotopic ossification. Herein, we developed manganese ferrite nanoparticles modified by the aptamer CH6 (CH6-MF NPs) that can efficiently scavenge ROS and actively deliver siRNA into hMSCs and osteoblasts in vivo for effective AS treatment. CH6-MF NPs loaded with BMP2 siRNA (CH6-MF-Si NPs) effectively suppressed abnormal osteogenic differentiation under inflammatory conditions in vitro. During their circulation and passive accumulation in inflamed joints in the Zap70(mut) mouse model, CH6-MF-Si NPs attenuated local inflammation and rescued heterotopic ossification in the entheses. Thus, CH6-MF NPs may be an effective inflammation reliever and osteoblast-specific delivery system, and CH6-MF-Si NPs have potential for the dual treatment of chronic inflammation and heterotopic ossification in AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01906-2. BioMed Central 2023-05-26 /pmc/articles/PMC10214592/ /pubmed/37231465 http://dx.doi.org/10.1186/s12951-023-01906-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zheng, Guan
Peng, Xiaoshuai
Zhang, Yunhui
Wang, Peng
Xie, Zhongyu
Li, Jinteng
Liu, Wenjie
Ye, Guiwen
Lin, Yucong
Li, Guojian
Liu, Huatao
Zeng, Chenying
Li, Lihua
Wu, Yanfeng
Shen, Huiyong
A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title_full A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title_fullStr A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title_full_unstemmed A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title_short A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
title_sort novel anti-ros osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214592/
https://www.ncbi.nlm.nih.gov/pubmed/37231465
http://dx.doi.org/10.1186/s12951-023-01906-2
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