Cargando…

Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia

Mechanical allodynia and hyperalgesia are intractable symptoms lacking effective clinical treatments in patients with neuropathic pain. However, whether and how mechanically responsive non-peptidergic nociceptors are involved remains elusive. Here, we showed that von Frey-evoked static allodynia and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Liangbiao, Su, Xiaojing, Yan, Jinjin, Wu, Qiaofeng, Xu, Xiang, Wang, Xinyue, Liu, Xiaoqing, Song, Xiaoyuan, Zhang, Zhi, Hu, Wei, Liu, Xinfeng, Zhang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214713/ https://www.ncbi.nlm.nih.gov/pubmed/37250305 http://dx.doi.org/10.1016/j.isci.2023.106764

Ejemplares similares

Mrgprd(Cre) lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit
por: Warwick, Charles, et al.
Publicado: (2021)

Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs
por: Reynders, Ana, et al.
Publicado: (2015)

Expression and localization of MrgprD in mouse intestinal tract
por: Zhou, Chenxing, et al.
Publicado: (2019)

Analysis of cutaneous MRGPRD free nerve endings and C-LTMRs transcriptomes by RNA-sequencing
por: Reynders, Ana, et al.
Publicado: (2015)

Identification of Physiologically Active Substances as Novel Ligands for MRGPRD
por: Uno, Makiko, et al.
Publicado: (2012)

Mechanical allodynia
por: Lolignier, Stéphane, et al.
Publicado: (2014)

Drosophila mechanical nociceptors preferentially sense localized poking
por: Liu, Zhen, et al.
Publicado: (2022)

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
por: Richner, Mette, et al.
Publicado: (2011)

The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation
por: Lee, Ju Hwan, et al.
Publicado: (2014)

Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury
por: Wang, Qun, et al.
Publicado: (2015)

Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats
por: Hu, Rong, et al.
Publicado: (2016)

Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain
por: Nencini, Sara, et al.
Publicado: (2017)

Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats
por: Matsuura, Kae, et al.
Publicado: (2021)

Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation
por: Zhan, Hongrui, et al.
Publicado: (2020)

Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model
por: Clifford, John L., et al.
Publicado: (2015)

Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors
por: Mathivanan, Sakthikumar, et al.
Publicado: (2016)

Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats
por: Mao-Ying, Qi-Liang, et al.
Publicado: (2012)

Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation
por: Fukuda, Taeko, et al.
Publicado: (2015)

Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury
por: Wlaschin, Josette J, et al.
Publicado: (2018)

The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice
por: Zhi, Yu-Ru, et al.
Publicado: (2022)

Spinal Cord Stimulation Attenuates Mechanical Allodynia and Increases Central Resolvin D1 Levels in Rats With Spared Nerve Injury
por: Tao, Xueshu, et al.
Publicado: (2021)

Role of TMEM100 in mechanically insensitive nociceptor un-silencing
por: Nees, Timo A., et al.
Publicado: (2023)

Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons
por: Zhang, Yunwen, et al.
Publicado: (2022)

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
por: Liu, Lei, et al.
Publicado: (2023)

Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation
por: Choi, Yun-Sik, et al.
Publicado: (2013)

Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia
por: Kim, Hwisung, et al.
Publicado: (2017)

Effect of two-week continuous epidural administration of 2% lidocaine on mechanical allodynia induced by spinal nerve ligation in rats
por: Cheong, Yuseon, et al.
Publicado: (2020)

Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors
por: Kerstein, Patrick C, et al.
Publicado: (2009)

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation
por: Lennertz, Richard C., et al.
Publicado: (2012)

Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK1/2 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat
por: Wang, Qi, et al.
Publicado: (2018)

Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats
por: Ahlström, F.H.G., et al.
Publicado: (2021)

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
por: Obeidat, Alia M., et al.
Publicado: (2023)

Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats
por: Yin, Yuhua, et al.
Publicado: (2019)

An effective and concise device for detecting cold allodynia in mice
por: Ruan, Yonglan, et al.
Publicado: (2018)

Oxytocin in the paraventricular nucleus attenuates incision-induced mechanical allodynia
por: ZHANG, YANFENG, et al.
Publicado: (2015)

Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury
por: Joukal, Marek, et al.
Publicado: (2020)

Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model
por: Ji, Xi-Tuan, et al.
Publicado: (2013)

STING mediates experimental osteoarthritis and mechanical allodynia in mouse
por: Shin, Youngnim, et al.
Publicado: (2023)

Dietary phytate induces subclinical mechanical allodynia in mice
por: Matias, D.O., et al.
Publicado: (2023)

A Single Injection of rAAV-shmTOR in Peripheral Nerve Persistently Attenuates Nerve Injury-Induced Mechanical Allodynia
por: Park, Minkyung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_05dcdm568t02iqog266squ50n0