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Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study

OBJECTIVES: To evaluate the feasibility of a novel and simple smart phone-based Retinopathy of Prematurity (ROP) screening approach in a resource-constrained setting. METHODS: This cross-sectional validation study was conducted at the Department of Ophthalmology and Neonatal Intensive Care Unit (NIC...

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Autores principales: Choudhary, Roha Ahmad, Hashmi, Shiraz, Tayyab, Haroon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214799/
https://www.ncbi.nlm.nih.gov/pubmed/37250571
http://dx.doi.org/10.12669/pjms.39.3.7053
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author Choudhary, Roha Ahmad
Hashmi, Shiraz
Tayyab, Haroon
author_facet Choudhary, Roha Ahmad
Hashmi, Shiraz
Tayyab, Haroon
author_sort Choudhary, Roha Ahmad
collection PubMed
description OBJECTIVES: To evaluate the feasibility of a novel and simple smart phone-based Retinopathy of Prematurity (ROP) screening approach in a resource-constrained setting. METHODS: This cross-sectional validation study was conducted at the Department of Ophthalmology and Neonatal Intensive Care Unit (NICU) of The Aga Khan University Hospital, Pakistan, from January 2022 to April 2022. A total of 63 images of eyes with active ROP (stage-1, 2, 3, 4 and/or plus or pre-plus disease) were included in this study. The stage of ROP was documented by the principal investigator using an indirect ophthalmoscope and retinal images were obtained using this novel technique. These images were shared with two masked ROP experts who rated the image quality and determined the stage of ROP and presence of plus disease. Their reports were compared with the initial findings reported by principal investigator using indirect ophthalmoscope. RESULTS: We reviewed 63 images for image quality, stage of ROP and presence of plus disease. There was significant agreement between the gold standard and the Rater-1 and 2 for the presence of plus disease (Cohen’s kappa was 0.84 and 1.0) and the stage of the disease (Cohen’s kappa 0.65 and 1.0). There was significant agreement between the Rater for presence of plus disease and any stage of ROP (Cohen’s κ: 0.84 and 0.65 for plus disease and any stage of the ROP, respectively). Rater-1 and 2 rated 96.83% and 98.41% images as excellent / acceptable respectively. CONCLUSIONS: High quality retinal images can be captured with a smartphone and 28D lens without using any additional adapter equipment. This approach of ROP screening can form basis of telemedicine for ROP in resource constrained areas.
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spelling pubmed-102147992023-05-27 Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study Choudhary, Roha Ahmad Hashmi, Shiraz Tayyab, Haroon Pak J Med Sci Original Article OBJECTIVES: To evaluate the feasibility of a novel and simple smart phone-based Retinopathy of Prematurity (ROP) screening approach in a resource-constrained setting. METHODS: This cross-sectional validation study was conducted at the Department of Ophthalmology and Neonatal Intensive Care Unit (NICU) of The Aga Khan University Hospital, Pakistan, from January 2022 to April 2022. A total of 63 images of eyes with active ROP (stage-1, 2, 3, 4 and/or plus or pre-plus disease) were included in this study. The stage of ROP was documented by the principal investigator using an indirect ophthalmoscope and retinal images were obtained using this novel technique. These images were shared with two masked ROP experts who rated the image quality and determined the stage of ROP and presence of plus disease. Their reports were compared with the initial findings reported by principal investigator using indirect ophthalmoscope. RESULTS: We reviewed 63 images for image quality, stage of ROP and presence of plus disease. There was significant agreement between the gold standard and the Rater-1 and 2 for the presence of plus disease (Cohen’s kappa was 0.84 and 1.0) and the stage of the disease (Cohen’s kappa 0.65 and 1.0). There was significant agreement between the Rater for presence of plus disease and any stage of ROP (Cohen’s κ: 0.84 and 0.65 for plus disease and any stage of the ROP, respectively). Rater-1 and 2 rated 96.83% and 98.41% images as excellent / acceptable respectively. CONCLUSIONS: High quality retinal images can be captured with a smartphone and 28D lens without using any additional adapter equipment. This approach of ROP screening can form basis of telemedicine for ROP in resource constrained areas. Professional Medical Publications 2023 /pmc/articles/PMC10214799/ /pubmed/37250571 http://dx.doi.org/10.12669/pjms.39.3.7053 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choudhary, Roha Ahmad
Hashmi, Shiraz
Tayyab, Haroon
Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title_full Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title_fullStr Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title_full_unstemmed Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title_short Smartphone-based fundus imaging for evaluation of Retinopathy of Prematurity in a low-income country: A pilot study
title_sort smartphone-based fundus imaging for evaluation of retinopathy of prematurity in a low-income country: a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214799/
https://www.ncbi.nlm.nih.gov/pubmed/37250571
http://dx.doi.org/10.12669/pjms.39.3.7053
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