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Oral microbiota in children with type 1 diabetes mellitus
INTRODUCTION: The oral cavity is a unique ecosystem in which the microbiome is formed by the colonization of billions of bacteria, viruses, and fungi. AIM OF THE STUDY: was to assess the quality and quantity of bacterial microbiota of the oral cavity in children with type 1 diabetes in comparison to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214943/ https://www.ncbi.nlm.nih.gov/pubmed/33878853 http://dx.doi.org/10.5114/pedm.2021.104343 |
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author | Pachoński, Marek Koczor-Rozmus, Aleksandra Mocny-Pachońska, Katarzyna Łanowy, Patrycja Mertas, Anna Jarosz-Chobot, Przemysława |
author_facet | Pachoński, Marek Koczor-Rozmus, Aleksandra Mocny-Pachońska, Katarzyna Łanowy, Patrycja Mertas, Anna Jarosz-Chobot, Przemysława |
author_sort | Pachoński, Marek |
collection | PubMed |
description | INTRODUCTION: The oral cavity is a unique ecosystem in which the microbiome is formed by the colonization of billions of bacteria, viruses, and fungi. AIM OF THE STUDY: was to assess the quality and quantity of bacterial microbiota of the oral cavity in children with type 1 diabetes in comparison to healthy children. MATERIAL AND METHODS: The study group consisted of 50 randomly selected type 1 diabetic children aged 10–18 years divided into 2 groups (25 people each) according to the level of diabetes control: well-controlled group (WC) – HbA(1c) ≤ 7.5%) and poorly-controlled group (PC) – HbA(1c) > 7.5%. The control group (GC) consisted of 25 randomly selected children with no systemic diseases. The material for microbiological tests was collected as two swabs: one from the bottom of the oral cavity and the other one from the posterior part of the dorsum of the tongue). RESULTS: The statistical analysis revealed statistically significant differences in the total number of isolated microorganisms between PC and GC (post hoc test p = 0.003) and WC and GC (post hoc test p < 0.001). There were no statistically significant differences in the number of isolated microorganisms between PC and WC (p = 0.195). CONCLUSIONS: Oral microbiome in type 1 diabetic children is significantly quantitatively different in comparison to healthy children. There are also visible qualitative differences in the profile of oral microbiota in type 1 diabetic children and healthy children. |
format | Online Article Text |
id | pubmed-10214943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-102149432023-06-05 Oral microbiota in children with type 1 diabetes mellitus Pachoński, Marek Koczor-Rozmus, Aleksandra Mocny-Pachońska, Katarzyna Łanowy, Patrycja Mertas, Anna Jarosz-Chobot, Przemysława Pediatr Endocrinol Diabetes Metab Original paper | Praca oryginalna INTRODUCTION: The oral cavity is a unique ecosystem in which the microbiome is formed by the colonization of billions of bacteria, viruses, and fungi. AIM OF THE STUDY: was to assess the quality and quantity of bacterial microbiota of the oral cavity in children with type 1 diabetes in comparison to healthy children. MATERIAL AND METHODS: The study group consisted of 50 randomly selected type 1 diabetic children aged 10–18 years divided into 2 groups (25 people each) according to the level of diabetes control: well-controlled group (WC) – HbA(1c) ≤ 7.5%) and poorly-controlled group (PC) – HbA(1c) > 7.5%. The control group (GC) consisted of 25 randomly selected children with no systemic diseases. The material for microbiological tests was collected as two swabs: one from the bottom of the oral cavity and the other one from the posterior part of the dorsum of the tongue). RESULTS: The statistical analysis revealed statistically significant differences in the total number of isolated microorganisms between PC and GC (post hoc test p = 0.003) and WC and GC (post hoc test p < 0.001). There were no statistically significant differences in the number of isolated microorganisms between PC and WC (p = 0.195). CONCLUSIONS: Oral microbiome in type 1 diabetic children is significantly quantitatively different in comparison to healthy children. There are also visible qualitative differences in the profile of oral microbiota in type 1 diabetic children and healthy children. Termedia Publishing House 2021-04-20 2021-06 /pmc/articles/PMC10214943/ /pubmed/33878853 http://dx.doi.org/10.5114/pedm.2021.104343 Text en Copyright © Polish Society of Pediatric Endocrinology and Diabetes https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), allowing third parties to download and share its works but not commercially purposes or to create derivative works. |
spellingShingle | Original paper | Praca oryginalna Pachoński, Marek Koczor-Rozmus, Aleksandra Mocny-Pachońska, Katarzyna Łanowy, Patrycja Mertas, Anna Jarosz-Chobot, Przemysława Oral microbiota in children with type 1 diabetes mellitus |
title | Oral microbiota in children with type 1 diabetes mellitus |
title_full | Oral microbiota in children with type 1 diabetes mellitus |
title_fullStr | Oral microbiota in children with type 1 diabetes mellitus |
title_full_unstemmed | Oral microbiota in children with type 1 diabetes mellitus |
title_short | Oral microbiota in children with type 1 diabetes mellitus |
title_sort | oral microbiota in children with type 1 diabetes mellitus |
topic | Original paper | Praca oryginalna |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214943/ https://www.ncbi.nlm.nih.gov/pubmed/33878853 http://dx.doi.org/10.5114/pedm.2021.104343 |
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