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Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and large predicts variability in 6-mercaptopurine (6-MP) related toxicities. However, some individuals without genetic variants in TPMT still develop toxicity that necessitates 6-MP dose reduction or interruption....

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Detalles Bibliográficos
Autores principales:	Ali, Awol Mekonnen, Adam, Haileyesus, Hailu, Daniel, Engidawork, Ephrem, Howe, Rawleigh, Abula, Teferra, Coenen, Marieke J. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214954/ https://www.ncbi.nlm.nih.gov/pubmed/37251339 http://dx.doi.org/10.3389/fphar.2023.1159307

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