Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity

Aspartic acid (Asp) isomerization is a spontaneous non-enzymatic post-translation modification causing a change in the structure of the protein backbone, which is commonly observed in therapeutic antibodies during manufacturing and storage. The Asps in Asp–Gly (DG), Asp–Ser (DS), and Asp–Thr (DT) mo...

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Detalles Bibliográficos
Autores principales: Yi, Meiqi, Sun, Jian, Sun, Hanzi, Wang, Yifei, Hou, Shan, Jiang, Beibei, Xie, Yuanyuan, Ji, Ruyue, Xue, Liu, Ding, Xiao, Song, Xiaomin, Xu, April, Huang, Chichi, Quan, Quan, Song, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215015/
https://www.ncbi.nlm.nih.gov/pubmed/37229604
http://dx.doi.org/10.1080/19420862.2023.2215364

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