Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses

Live poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs,...

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Autores principales: Wang, Zhen, Li, Hongkui, Li, Yuhan, Wu, Zhuanli, Ai, Hui, Zhang, Ming, Rong, Libin, Blinov, Michael L., Tong, Qi, Liu, Litao, Sun, Honglei, Pu, Juan, Feng, Wenhai, Liu, Jinhua, Sun, Yipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215028/
https://www.ncbi.nlm.nih.gov/pubmed/37191631
http://dx.doi.org/10.1080/22221751.2023.2214255
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author Wang, Zhen
Li, Hongkui
Li, Yuhan
Wu, Zhuanli
Ai, Hui
Zhang, Ming
Rong, Libin
Blinov, Michael L.
Tong, Qi
Liu, Litao
Sun, Honglei
Pu, Juan
Feng, Wenhai
Liu, Jinhua
Sun, Yipeng
author_facet Wang, Zhen
Li, Hongkui
Li, Yuhan
Wu, Zhuanli
Ai, Hui
Zhang, Ming
Rong, Libin
Blinov, Michael L.
Tong, Qi
Liu, Litao
Sun, Honglei
Pu, Juan
Feng, Wenhai
Liu, Jinhua
Sun, Yipeng
author_sort Wang, Zhen
collection PubMed
description Live poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs, which received poultry from the wholesale LPM but where different poultry species were sold in one stall, in Guangdong province from 2017 to 2019. A higher AIV isolation rate was observed at the retail LPMs than the wholesale LPM. H9N2 was the dominant AIV subtype and was mainly present in chickens and quails. The genetic diversity of H9N2 viruses was greater at the retail LPMs, where a complex system of two-way transmission between different poultry species had formed. The isolated H9N2 viruses could be classed into four genotypes: G57 and the three novel genotypes, NG164, NG165, and NG166. The H9N2 AIVs isolated from chickens and quails at the wholesale LPM only belonged to the G57 and NG164 genotypes, respectively. However, the G57, NG164, and NG165 genotypes were identified in both chickens and quails at the retail LPMs. We found that the replication and transmission of the NG165 genotype were more adaptive to both poultry and mammalian models than those of its precursor genotype, NG164. Our findings revealed that mixed poultry selling at retail LPMs has increased the genetic diversity of AIVs, which might facilitate the emergence of novel viruses that threaten public health.
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spelling pubmed-102150282023-05-27 Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses Wang, Zhen Li, Hongkui Li, Yuhan Wu, Zhuanli Ai, Hui Zhang, Ming Rong, Libin Blinov, Michael L. Tong, Qi Liu, Litao Sun, Honglei Pu, Juan Feng, Wenhai Liu, Jinhua Sun, Yipeng Emerg Microbes Infect Influenza Infections Live poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs, which received poultry from the wholesale LPM but where different poultry species were sold in one stall, in Guangdong province from 2017 to 2019. A higher AIV isolation rate was observed at the retail LPMs than the wholesale LPM. H9N2 was the dominant AIV subtype and was mainly present in chickens and quails. The genetic diversity of H9N2 viruses was greater at the retail LPMs, where a complex system of two-way transmission between different poultry species had formed. The isolated H9N2 viruses could be classed into four genotypes: G57 and the three novel genotypes, NG164, NG165, and NG166. The H9N2 AIVs isolated from chickens and quails at the wholesale LPM only belonged to the G57 and NG164 genotypes, respectively. However, the G57, NG164, and NG165 genotypes were identified in both chickens and quails at the retail LPMs. We found that the replication and transmission of the NG165 genotype were more adaptive to both poultry and mammalian models than those of its precursor genotype, NG164. Our findings revealed that mixed poultry selling at retail LPMs has increased the genetic diversity of AIVs, which might facilitate the emergence of novel viruses that threaten public health. Taylor & Francis 2023-05-25 /pmc/articles/PMC10215028/ /pubmed/37191631 http://dx.doi.org/10.1080/22221751.2023.2214255 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Influenza Infections
Wang, Zhen
Li, Hongkui
Li, Yuhan
Wu, Zhuanli
Ai, Hui
Zhang, Ming
Rong, Libin
Blinov, Michael L.
Tong, Qi
Liu, Litao
Sun, Honglei
Pu, Juan
Feng, Wenhai
Liu, Jinhua
Sun, Yipeng
Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title_full Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title_fullStr Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title_full_unstemmed Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title_short Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
title_sort mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
topic Influenza Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215028/
https://www.ncbi.nlm.nih.gov/pubmed/37191631
http://dx.doi.org/10.1080/22221751.2023.2214255
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