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Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model

Background: Heightened levels of inflammation and oxidative stress are thought to be involved in the pathophysiology of schizophrenia. We aimed to assess whether intake of anti-inflammatory and anti-oxidant drugs during pregnancy prevents later schizophrenia-related outcomes in a neurodevelopmental...

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Autores principales: Edemann-Callesen, Henriette, Bernhardt, Nadine, Hlusicka, Elizabeth Barroeta, Hintz, Franziska, Habelt, Bettina, Winter, Rebecca, Neubert, Isabell, Pelz, Meike, Filla, Alexandra, Soto-Montenegro, Maria Luisa, Winter, Christine, Hadar, Ravit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215079/
https://www.ncbi.nlm.nih.gov/pubmed/37237933
http://dx.doi.org/10.3390/antiox12051068
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author Edemann-Callesen, Henriette
Bernhardt, Nadine
Hlusicka, Elizabeth Barroeta
Hintz, Franziska
Habelt, Bettina
Winter, Rebecca
Neubert, Isabell
Pelz, Meike
Filla, Alexandra
Soto-Montenegro, Maria Luisa
Winter, Christine
Hadar, Ravit
author_facet Edemann-Callesen, Henriette
Bernhardt, Nadine
Hlusicka, Elizabeth Barroeta
Hintz, Franziska
Habelt, Bettina
Winter, Rebecca
Neubert, Isabell
Pelz, Meike
Filla, Alexandra
Soto-Montenegro, Maria Luisa
Winter, Christine
Hadar, Ravit
author_sort Edemann-Callesen, Henriette
collection PubMed
description Background: Heightened levels of inflammation and oxidative stress are thought to be involved in the pathophysiology of schizophrenia. We aimed to assess whether intake of anti-inflammatory and anti-oxidant drugs during pregnancy prevents later schizophrenia-related outcomes in a neurodevelopmental rat model of this disorder. Methods: Pregnant Wistar rats were injected with polyriboinosinic–polyribocytidilic acid (Poly I:C) or saline and subsequently treated with either N-acetyl cysteine (NAC) or omega-3 polyunsaturated fatty acids (PUFAs) until delivery. Controls rats received no treatment. In the offspring, neuroinflammation and anti-oxidant enzyme activity were assessed on postnatal day (PND) 21, 33, 48, and 90. Behavioral testing was performed at PND 90, followed by post-mortem neurochemical assessment and ex vivo MRI. Results: The supplement treatment led to a quicker restoration of the wellbeing of dams. In the adolescent Poly I:C offspring, the supplement treatment prevented an increase in microglial activity and partially prevented a deregulation in the anti-oxidant defense system. In the adult Poly I:C offspring, supplement treatment partially prevented dopamine deficits, which was paralleled by some changes in behavior. Exposure to omega-3 PUFAs prevented the enlargement of lateral ventricles. Conclusion: Intake of over-the-counter supplements may assist in especially targeting the inflammatory response related to schizophrenia pathophysiology, aiding in diminishing later disease severity in the offspring.
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spelling pubmed-102150792023-05-27 Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model Edemann-Callesen, Henriette Bernhardt, Nadine Hlusicka, Elizabeth Barroeta Hintz, Franziska Habelt, Bettina Winter, Rebecca Neubert, Isabell Pelz, Meike Filla, Alexandra Soto-Montenegro, Maria Luisa Winter, Christine Hadar, Ravit Antioxidants (Basel) Article Background: Heightened levels of inflammation and oxidative stress are thought to be involved in the pathophysiology of schizophrenia. We aimed to assess whether intake of anti-inflammatory and anti-oxidant drugs during pregnancy prevents later schizophrenia-related outcomes in a neurodevelopmental rat model of this disorder. Methods: Pregnant Wistar rats were injected with polyriboinosinic–polyribocytidilic acid (Poly I:C) or saline and subsequently treated with either N-acetyl cysteine (NAC) or omega-3 polyunsaturated fatty acids (PUFAs) until delivery. Controls rats received no treatment. In the offspring, neuroinflammation and anti-oxidant enzyme activity were assessed on postnatal day (PND) 21, 33, 48, and 90. Behavioral testing was performed at PND 90, followed by post-mortem neurochemical assessment and ex vivo MRI. Results: The supplement treatment led to a quicker restoration of the wellbeing of dams. In the adolescent Poly I:C offspring, the supplement treatment prevented an increase in microglial activity and partially prevented a deregulation in the anti-oxidant defense system. In the adult Poly I:C offspring, supplement treatment partially prevented dopamine deficits, which was paralleled by some changes in behavior. Exposure to omega-3 PUFAs prevented the enlargement of lateral ventricles. Conclusion: Intake of over-the-counter supplements may assist in especially targeting the inflammatory response related to schizophrenia pathophysiology, aiding in diminishing later disease severity in the offspring. MDPI 2023-05-09 /pmc/articles/PMC10215079/ /pubmed/37237933 http://dx.doi.org/10.3390/antiox12051068 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Edemann-Callesen, Henriette
Bernhardt, Nadine
Hlusicka, Elizabeth Barroeta
Hintz, Franziska
Habelt, Bettina
Winter, Rebecca
Neubert, Isabell
Pelz, Meike
Filla, Alexandra
Soto-Montenegro, Maria Luisa
Winter, Christine
Hadar, Ravit
Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title_full Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title_fullStr Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title_full_unstemmed Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title_short Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model
title_sort supplement treatment with nac and omega-3 polyunsaturated fatty acids during pregnancy partially prevents schizophrenia-related outcomes in the poly i:c rat model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215079/
https://www.ncbi.nlm.nih.gov/pubmed/37237933
http://dx.doi.org/10.3390/antiox12051068
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