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D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides

Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non-proteinogenic amino acids to improve their therapeutic properties. The physicochemical properties of these analogs were analyzed, in...

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Detalles Bibliográficos
Autores principales:	Humpola, Maria Veronica, Spinelli, Roque, Erben, Melina, Perdomo, Virginia, Tonarelli, Georgina Guadalupe, Albericio, Fernando, Siano, Alvaro Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215143/ https://www.ncbi.nlm.nih.gov/pubmed/37237724 http://dx.doi.org/10.3390/antibiotics12050821

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