Cargando…
Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension
Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215203/ https://www.ncbi.nlm.nih.gov/pubmed/37237872 http://dx.doi.org/10.3390/antiox12051006 |
_version_ | 1785048007509540864 |
---|---|
author | Poyatos, Paula Gratacós, Miquel Samuel, Kay Orriols, Ramon Tura-Ceide, Olga |
author_facet | Poyatos, Paula Gratacós, Miquel Samuel, Kay Orriols, Ramon Tura-Ceide, Olga |
author_sort | Poyatos, Paula |
collection | PubMed |
description | Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology. Alteration of redox homeostasis produces excessive generation of reactive oxygen species, inducing oxidative stress and the subsequent alteration of biological molecules. Exacerbations in oxidative stress production can lead to alterations in nitric oxide signaling pathways, contributing to the proliferation of pulmonary arterial endothelial cells and smooth muscle cells, inducing PH development. Recently, antioxidant therapy has been suggested as a novel therapeutic strategy for PH pathology. However, the favorable outcomes observed in preclinical studies have not been consistently reproduced in clinical practice. Therefore, targeting oxidative stress as a therapeutic intervention for PH is an area that is still being explored. This review summarizes the contribution of oxidative stress to the pathogenesis of the different types of PH and suggests antioxidant therapy as a promising strategy for PH treatment. |
format | Online Article Text |
id | pubmed-10215203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102152032023-05-27 Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension Poyatos, Paula Gratacós, Miquel Samuel, Kay Orriols, Ramon Tura-Ceide, Olga Antioxidants (Basel) Review Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology. Alteration of redox homeostasis produces excessive generation of reactive oxygen species, inducing oxidative stress and the subsequent alteration of biological molecules. Exacerbations in oxidative stress production can lead to alterations in nitric oxide signaling pathways, contributing to the proliferation of pulmonary arterial endothelial cells and smooth muscle cells, inducing PH development. Recently, antioxidant therapy has been suggested as a novel therapeutic strategy for PH pathology. However, the favorable outcomes observed in preclinical studies have not been consistently reproduced in clinical practice. Therefore, targeting oxidative stress as a therapeutic intervention for PH is an area that is still being explored. This review summarizes the contribution of oxidative stress to the pathogenesis of the different types of PH and suggests antioxidant therapy as a promising strategy for PH treatment. MDPI 2023-04-26 /pmc/articles/PMC10215203/ /pubmed/37237872 http://dx.doi.org/10.3390/antiox12051006 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Poyatos, Paula Gratacós, Miquel Samuel, Kay Orriols, Ramon Tura-Ceide, Olga Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title_full | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title_fullStr | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title_full_unstemmed | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title_short | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
title_sort | oxidative stress and antioxidant therapy in pulmonary hypertension |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215203/ https://www.ncbi.nlm.nih.gov/pubmed/37237872 http://dx.doi.org/10.3390/antiox12051006 |
work_keys_str_mv | AT poyatospaula oxidativestressandantioxidanttherapyinpulmonaryhypertension AT gratacosmiquel oxidativestressandantioxidanttherapyinpulmonaryhypertension AT samuelkay oxidativestressandantioxidanttherapyinpulmonaryhypertension AT orriolsramon oxidativestressandantioxidanttherapyinpulmonaryhypertension AT turaceideolga oxidativestressandantioxidanttherapyinpulmonaryhypertension |