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Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia
The objective of this study was to characterize the distribution of antimicrobial resistance (AMR) of Escherichia coli (E. coli) isolated from livestock feces and soil in smallholder livestock systems. A cross-sectional study was carried out sampling 77 randomly selected households in four districts...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215241/ https://www.ncbi.nlm.nih.gov/pubmed/37237844 http://dx.doi.org/10.3390/antibiotics12050941 |
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author | Gemeda, Biruk Alemu Wieland, Barbara Alemayehu, Gezahegn Knight-Jones, Theodore J. D. Wodajo, Hiwot Desta Tefera, Misgana Kumbe, Adem Olani, Abebe Abera, Shubisa Amenu, Kebede |
author_facet | Gemeda, Biruk Alemu Wieland, Barbara Alemayehu, Gezahegn Knight-Jones, Theodore J. D. Wodajo, Hiwot Desta Tefera, Misgana Kumbe, Adem Olani, Abebe Abera, Shubisa Amenu, Kebede |
author_sort | Gemeda, Biruk Alemu |
collection | PubMed |
description | The objective of this study was to characterize the distribution of antimicrobial resistance (AMR) of Escherichia coli (E. coli) isolated from livestock feces and soil in smallholder livestock systems. A cross-sectional study was carried out sampling 77 randomly selected households in four districts representing two agroecologies and production systems. E. coli was isolated and the susceptibility to 15 antimicrobials was assessed. Of 462 E. coli isolates tested, resistance to at least one antimicrobial was detected in 52% (43.7–60.8) of isolates from cattle fecal samples, 34% (95% CI, 26.2–41.8) from sheep samples, 58% (95% CI, 47.9–68.2) from goat samples and 53% (95% CI, 43.2–62.4) from soil samples. AMR patterns for E. coli from livestock and soil showed some similarities, with the highest prevalence of resistance detected against streptomycin (33%), followed by amoxycillin/clavulanate (23%) and tetracycline (8%). The odds of detecting E. coli resistance to ≥2 antimicrobials in livestock fecal samples were nearly three times (Odd Ratio—OR: 2.9; 95% CI, 1.72–5.17; p = 0.000) higher in lowland pastoral than in highland mixed crop–livestock production systems. These findings provide insights into the status of resistance in livestock and soil, and associated risk factors in low-resource settings in Ethiopia. |
format | Online Article Text |
id | pubmed-10215241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102152412023-05-27 Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia Gemeda, Biruk Alemu Wieland, Barbara Alemayehu, Gezahegn Knight-Jones, Theodore J. D. Wodajo, Hiwot Desta Tefera, Misgana Kumbe, Adem Olani, Abebe Abera, Shubisa Amenu, Kebede Antibiotics (Basel) Article The objective of this study was to characterize the distribution of antimicrobial resistance (AMR) of Escherichia coli (E. coli) isolated from livestock feces and soil in smallholder livestock systems. A cross-sectional study was carried out sampling 77 randomly selected households in four districts representing two agroecologies and production systems. E. coli was isolated and the susceptibility to 15 antimicrobials was assessed. Of 462 E. coli isolates tested, resistance to at least one antimicrobial was detected in 52% (43.7–60.8) of isolates from cattle fecal samples, 34% (95% CI, 26.2–41.8) from sheep samples, 58% (95% CI, 47.9–68.2) from goat samples and 53% (95% CI, 43.2–62.4) from soil samples. AMR patterns for E. coli from livestock and soil showed some similarities, with the highest prevalence of resistance detected against streptomycin (33%), followed by amoxycillin/clavulanate (23%) and tetracycline (8%). The odds of detecting E. coli resistance to ≥2 antimicrobials in livestock fecal samples were nearly three times (Odd Ratio—OR: 2.9; 95% CI, 1.72–5.17; p = 0.000) higher in lowland pastoral than in highland mixed crop–livestock production systems. These findings provide insights into the status of resistance in livestock and soil, and associated risk factors in low-resource settings in Ethiopia. MDPI 2023-05-22 /pmc/articles/PMC10215241/ /pubmed/37237844 http://dx.doi.org/10.3390/antibiotics12050941 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gemeda, Biruk Alemu Wieland, Barbara Alemayehu, Gezahegn Knight-Jones, Theodore J. D. Wodajo, Hiwot Desta Tefera, Misgana Kumbe, Adem Olani, Abebe Abera, Shubisa Amenu, Kebede Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title | Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title_full | Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title_fullStr | Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title_full_unstemmed | Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title_short | Antimicrobial Resistance of Escherichia coli Isolates from Livestock and the Environment in Extensive Smallholder Livestock Production Systems in Ethiopia |
title_sort | antimicrobial resistance of escherichia coli isolates from livestock and the environment in extensive smallholder livestock production systems in ethiopia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215241/ https://www.ncbi.nlm.nih.gov/pubmed/37237844 http://dx.doi.org/10.3390/antibiotics12050941 |
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