mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines

SIMPLE SUMMARY: Tumor cell survival depends on the inter-connected activation of multiple pathways. Here, we show that acute myeloid leukemia cell lines benefit from an important inter-play between mTORC1-ERK and AKT, explaining why mTOR inhibition is rather ineffective in killing those cells. In fa...

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Detalles Bibliográficos
Autores principales: Germano, Concetta Anna, Clemente, Giuseppe, Storniolo, Antonello, Romeo, Maria Anele, Ferretti, Elisabetta, Cirone, Mara, Di Renzo, Livia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215294/
https://www.ncbi.nlm.nih.gov/pubmed/37237490
http://dx.doi.org/10.3390/biology12050676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215294/
https://www.ncbi.nlm.nih.gov/pubmed/37237490
http://dx.doi.org/10.3390/biology12050676

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