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Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Diabetic wound healing is a global medical challenge. Several studies showed that delayed healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive production of ROS and impaired ROS detoxification in diabetes are the main cause of chronic wounds. Indeed, increas...

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Autores principales: Accipe, Laura, Abadie, Alisson, Neviere, Remi, Bercion, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215346/
https://www.ncbi.nlm.nih.gov/pubmed/37237945
http://dx.doi.org/10.3390/antiox12051079
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author Accipe, Laura
Abadie, Alisson
Neviere, Remi
Bercion, Sylvie
author_facet Accipe, Laura
Abadie, Alisson
Neviere, Remi
Bercion, Sylvie
author_sort Accipe, Laura
collection PubMed
description Diabetic wound healing is a global medical challenge. Several studies showed that delayed healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive production of ROS and impaired ROS detoxification in diabetes are the main cause of chronic wounds. Indeed, increased ROS promotes the expression and activity of metalloproteinase, resulting in a high proteolytic state in the wound with significant destruction of the extracellular matrix, which leads to a stop in the repair process. In addition, ROS accumulation increases NLRP3 inflammasome activation and macrophage hyperpolarization in the M1 pro-inflammatory phenotype. Oxidative stress increases the activation of NETosis. This leads to an elevated pro-inflammatory state in the wound and prevents the resolution of inflammation, an essential step for wound healing. The use of medicinal plants and natural compounds can improve diabetic wound healing by directly targeting oxidative stress and the transcription factor Nrf2 involved in the antioxidant response or the mechanisms impacted by the elevation of ROS such as NLRP3 inflammasome, the polarization of macrophages, and expression or activation of metalloproteinases. This study of the diabetic pro-healing activity of nine plants found in the Caribbean highlights, more particularly, the role of five polyphenolic compounds. At the end of this review, research perspectives are presented.
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spelling pubmed-102153462023-05-27 Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing Accipe, Laura Abadie, Alisson Neviere, Remi Bercion, Sylvie Antioxidants (Basel) Review Diabetic wound healing is a global medical challenge. Several studies showed that delayed healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive production of ROS and impaired ROS detoxification in diabetes are the main cause of chronic wounds. Indeed, increased ROS promotes the expression and activity of metalloproteinase, resulting in a high proteolytic state in the wound with significant destruction of the extracellular matrix, which leads to a stop in the repair process. In addition, ROS accumulation increases NLRP3 inflammasome activation and macrophage hyperpolarization in the M1 pro-inflammatory phenotype. Oxidative stress increases the activation of NETosis. This leads to an elevated pro-inflammatory state in the wound and prevents the resolution of inflammation, an essential step for wound healing. The use of medicinal plants and natural compounds can improve diabetic wound healing by directly targeting oxidative stress and the transcription factor Nrf2 involved in the antioxidant response or the mechanisms impacted by the elevation of ROS such as NLRP3 inflammasome, the polarization of macrophages, and expression or activation of metalloproteinases. This study of the diabetic pro-healing activity of nine plants found in the Caribbean highlights, more particularly, the role of five polyphenolic compounds. At the end of this review, research perspectives are presented. MDPI 2023-05-11 /pmc/articles/PMC10215346/ /pubmed/37237945 http://dx.doi.org/10.3390/antiox12051079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Accipe, Laura
Abadie, Alisson
Neviere, Remi
Bercion, Sylvie
Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title_full Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title_fullStr Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title_full_unstemmed Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title_short Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
title_sort antioxidant activities of natural compounds from caribbean plants to enhance diabetic wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215346/
https://www.ncbi.nlm.nih.gov/pubmed/37237945
http://dx.doi.org/10.3390/antiox12051079
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