Cargando…

YAP Inhibition Alleviates Simulated Microgravity-Induced Mesenchymal Stem Cell Senescence via Targeting Mitochondrial Dysfunction

Weightlessness in space leads to bone loss, muscle atrophy, and impaired immune defense in astronauts. Mesenchymal stem cells (MSCs) play crucial roles in maintaining the homeostasis and function of the tissue. However, how microgravity affects the characteristics MSCs and the related roles in the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Wenjun, Peng, Xiufen, Tu, Yun, Shi, Yisong, Song, Guanbin, Luo, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215363/ https://www.ncbi.nlm.nih.gov/pubmed/37237856 http://dx.doi.org/10.3390/antiox12050990

Ejemplares similares

Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway
por: Cheng, Yansiwei, et al.
Publicado: (2021)

Simulated Microgravity Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting Oxidative Phosphorylation
por: Liu, Lin, et al.
Publicado: (2020)

Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation
por: Chen, Zhe, et al.
Publicado: (2016)

Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity
por: Thompson, Matthew, et al.
Publicado: (2020)

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity
por: Weiss, William M., et al.
Publicado: (2017)

Duration of simulated microgravity affects the differentiation of mesenchymal stem cells
por: Xue, Li, et al.
Publicado: (2017)

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
por: Arun, Raj Pranap, et al.
Publicado: (2019)

The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells
por: Ulbrich, Claudia, et al.
Publicado: (2014)

Mesenchymal Stem Cell Behavior under Microgravity: From Stress Response to a Premature Senescence
por: Pala, Renzo, et al.
Publicado: (2023)

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
por: Fu, Lina, et al.
Publicado: (2019)

The effects of real and simulated microgravity on cellular mitochondrial function
por: Nguyen, Hong Phuong, et al.
Publicado: (2021)

WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity
por: Zhong, Guohui, et al.
Publicado: (2021)

Effects of Simulated Microgravity on Embryonic Stem Cells
por: Wang, Yulan, et al.
Publicado: (2011)

Effects of Spaceflight and Simulated Microgravity on YAP1 Expression in Cardiovascular Progenitors: Implications for Cell-Based Repair
por: Camberos, Victor, et al.
Publicado: (2019)

Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes
por: Ranieri, Danilo, et al.
Publicado: (2017)

Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis
por: Ye, Guiwen, et al.
Publicado: (2020)

The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity
por: Ji, Guohua, et al.
Publicado: (2022)

Exogenous NAD(+) Postpones the D-Gal-Induced Senescence of Bone Marrow-Derived Mesenchymal Stem Cells via Sirt1 Signaling
por: Wang, Jie, et al.
Publicado: (2021)

Releasing YAP dysfunction‐caused replicative toxicity rejuvenates mesenchymal stem cells
por: Yu, Fanyuan, et al.
Publicado: (2023)

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis
por: Lei, Jinghui, et al.
Publicado: (2021)

Simulated microgravity modulates the mesenchymal stromal cell response to inflammatory stimulation
por: Ratushnyy, Andrey, et al.
Publicado: (2019)

Simulated Microgravity Remodels Extracellular Matrix of Osteocommitted Mesenchymal Stromal Cells
por: Zhivodernikov, Ivan, et al.
Publicado: (2021)

Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
por: Zhang, Weijun, et al.
Publicado: (2022)

LIF-Free Embryonic Stem Cell Culture in Simulated Microgravity
por: Kawahara, Yumi, et al.
Publicado: (2009)

Simulated microgravity significantly altered metabolism in epidermal stem cells
por: Li, Bin-Bin, et al.
Publicado: (2020)

Technology using simulated microgravity
por: Nishimura, Yusuke
Publicado: (2023)

Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin’s lymphoma cells
por: Jeong, Ae Jin, et al.
Publicado: (2018)

Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cells
por: Li, Liang, et al.
Publicado: (2018)

Enhanced self-renewal of human pluripotent stem cells by simulated microgravity
por: Timilsina, S., et al.
Publicado: (2022)

Melatonin suppresses senescence‐derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L–mitophagy pathway
por: Lee, Jun Hee, et al.
Publicado: (2020)

Effect of simulated microgravity conditions of hindlimb unloading on mice hematopoietic and mesenchymal stromal cells
por: Dai, Shiyun, et al.
Publicado: (2020)

Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling
por: He, Shan, et al.
Publicado: (2023)

Mesenchymal Stem Cell Migration and Tissue Repair
por: Fu, Xiaorong, et al.
Publicado: (2019)

The Emerging Role of Macrophages in Immune System Dysfunction under Real and Simulated Microgravity Conditions
por: Sun, Yulong, et al.
Publicado: (2021)

Planarians Sense Simulated Microgravity and Hypergravity
por: Adell, Teresa, et al.
Publicado: (2014)

Simulated microgravity in the ring-sheared drop
por: McMackin, Patrick M., et al.
Publicado: (2020)

The Effects of Simulated Microgravity on Macrophage Phenotype
por: Ludtka, Christopher, et al.
Publicado: (2021)

Adaptation to simulated microgravity in Streptococcus mutans
por: Fernander, Mizpha C., et al.
Publicado: (2022)

Downregulation of MicroRNA-206 Alleviates the Sublethal Oxidative Stress-Induced Premature Senescence and Dysfunction in Mesenchymal Stem Cells via Targeting Alpl
por: Liu, Xuan, et al.
Publicado: (2020)

Mitochondrial dysfunction in cell senescence and aging
por: Miwa, Satomi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_up41coj47rmh96k2611595e0be