Harnessing the Dual Antimicrobial Mechanism of Action with Fe(8-Hydroxyquinoline)(3) to Develop a Topical Ointment for Mupirocin-Resistant MRSA Infections

8-Hydroxyquinoline (8-hq) exhibits potent antimicrobial activity against Staphylococcus aureus (SA) bacteria with MIC = 16.0–32.0 µM owing to its ability to chelate metal ions such as Mn(2+), Zn(2+,) and Cu(2+) to disrupt metal homeostasis in bacterial cells. We demonstrate that Fe(8-hq)(3), the 1:3...

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Detalles Bibliográficos
Autores principales: Abeydeera, Nalin, Benin, Bogdan M., Mudarmah, Khalil, Pant, Bishnu D., Chen, Guanyu, Shin, Woo Shik, Kim, Min-Ho, Huang, Songping D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215364/
https://www.ncbi.nlm.nih.gov/pubmed/37237789
http://dx.doi.org/10.3390/antibiotics12050886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215364/
https://www.ncbi.nlm.nih.gov/pubmed/37237789
http://dx.doi.org/10.3390/antibiotics12050886

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