Cargando…

Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin

Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM....

Descripción completa

Detalles Bibliográficos
Autores principales: Corbacho-Alonso, Nerea, Rodríguez-Sánchez, Elena, Sastre-Oliva, Tamara, Mercado-García, Elisa, Perales-Sánchez, Ines, Juarez-Alia, Cristina, López-Almodovar, Luis F., Padial, Luis R., Tejerina, Teresa, Mourino-Alvarez, Laura, Ruiz-Hurtado, Gema, Barderas, María G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215415/
https://www.ncbi.nlm.nih.gov/pubmed/37237890
http://dx.doi.org/10.3390/antiox12051024
_version_ 1785048057432244224
author Corbacho-Alonso, Nerea
Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María G.
author_facet Corbacho-Alonso, Nerea
Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María G.
author_sort Corbacho-Alonso, Nerea
collection PubMed
description Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine.
format Online
Article
Text
id pubmed-10215415
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102154152023-05-27 Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin Corbacho-Alonso, Nerea Rodríguez-Sánchez, Elena Sastre-Oliva, Tamara Mercado-García, Elisa Perales-Sánchez, Ines Juarez-Alia, Cristina López-Almodovar, Luis F. Padial, Luis R. Tejerina, Teresa Mourino-Alvarez, Laura Ruiz-Hurtado, Gema Barderas, María G. Antioxidants (Basel) Article Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine. MDPI 2023-04-28 /pmc/articles/PMC10215415/ /pubmed/37237890 http://dx.doi.org/10.3390/antiox12051024 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corbacho-Alonso, Nerea
Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María G.
Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_full Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_fullStr Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_full_unstemmed Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_short Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_sort global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215415/
https://www.ncbi.nlm.nih.gov/pubmed/37237890
http://dx.doi.org/10.3390/antiox12051024
work_keys_str_mv AT corbachoalonsonerea globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT rodriguezsanchezelena globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT sastreolivatamara globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT mercadogarciaelisa globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT peralessanchezines globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT juarezaliacristina globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT lopezalmodovarluisf globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT padialluisr globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT tejerinateresa globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT mourinoalvarezlaura globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT ruizhurtadogema globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin
AT barderasmariag globaloxidativestatusislinkedtocalcificaorticstenosisthedifferencesduetodiabetesmellitusandtheeffectsofmetformin