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Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions

Microbiological data are used as indicators of infection, for diagnosis, and the identification of antimicrobial resistance in trials of antimicrobial stewardship interventions. However, several problems have been identified in a recently conducted systematic review (e.g., inconsistency in reporting...

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Autores principales: Lau, Tin Man Mandy, Daniel, Rhian, Hood, Kerenza, Wootton, Mandy, Hughes, Kathryn, Stuart, Beth, Hayward, Gail, Szakmany, Tamas, Gillespie, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215498/
https://www.ncbi.nlm.nih.gov/pubmed/37237788
http://dx.doi.org/10.3390/antibiotics12050885
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author Lau, Tin Man Mandy
Daniel, Rhian
Hood, Kerenza
Wootton, Mandy
Hughes, Kathryn
Stuart, Beth
Hayward, Gail
Szakmany, Tamas
Gillespie, David
author_facet Lau, Tin Man Mandy
Daniel, Rhian
Hood, Kerenza
Wootton, Mandy
Hughes, Kathryn
Stuart, Beth
Hayward, Gail
Szakmany, Tamas
Gillespie, David
author_sort Lau, Tin Man Mandy
collection PubMed
description Microbiological data are used as indicators of infection, for diagnosis, and the identification of antimicrobial resistance in trials of antimicrobial stewardship interventions. However, several problems have been identified in a recently conducted systematic review (e.g., inconsistency in reporting and oversimplified outcomes), which motivates the need to understand and improve the use of these data including analysis and reporting. We engaged key stakeholders including statisticians, clinicians from both primary and secondary care, and microbiologists. Discussions included issues identified in the systematic review and questions about the value of using microbiological data in clinical trials, perspectives on current microbiological outcomes reported in trials, and alternative statistical approaches to analyse these data. Various factors (such as unclear sample collection process, dichotomising or categorising complex microbiological data, and unclear methods of handling missing data) were identified that contributed to the low quality of the microbiological outcomes and the analysis of these outcomes in trials. Whilst not all of these factors would be easy to overcome, there is room for improvement and a need to encourage researchers to understand the impact of misusing these data. This paper discusses the experience and challenges of using microbiological outcomes in clinical trials.
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spelling pubmed-102154982023-05-27 Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions Lau, Tin Man Mandy Daniel, Rhian Hood, Kerenza Wootton, Mandy Hughes, Kathryn Stuart, Beth Hayward, Gail Szakmany, Tamas Gillespie, David Antibiotics (Basel) Brief Report Microbiological data are used as indicators of infection, for diagnosis, and the identification of antimicrobial resistance in trials of antimicrobial stewardship interventions. However, several problems have been identified in a recently conducted systematic review (e.g., inconsistency in reporting and oversimplified outcomes), which motivates the need to understand and improve the use of these data including analysis and reporting. We engaged key stakeholders including statisticians, clinicians from both primary and secondary care, and microbiologists. Discussions included issues identified in the systematic review and questions about the value of using microbiological data in clinical trials, perspectives on current microbiological outcomes reported in trials, and alternative statistical approaches to analyse these data. Various factors (such as unclear sample collection process, dichotomising or categorising complex microbiological data, and unclear methods of handling missing data) were identified that contributed to the low quality of the microbiological outcomes and the analysis of these outcomes in trials. Whilst not all of these factors would be easy to overcome, there is room for improvement and a need to encourage researchers to understand the impact of misusing these data. This paper discusses the experience and challenges of using microbiological outcomes in clinical trials. MDPI 2023-05-10 /pmc/articles/PMC10215498/ /pubmed/37237788 http://dx.doi.org/10.3390/antibiotics12050885 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Lau, Tin Man Mandy
Daniel, Rhian
Hood, Kerenza
Wootton, Mandy
Hughes, Kathryn
Stuart, Beth
Hayward, Gail
Szakmany, Tamas
Gillespie, David
Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title_full Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title_fullStr Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title_full_unstemmed Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title_short Perspectives of Statistician, Microbiologist, and Clinician Stakeholders on the Use of Microbiological Outcomes in Randomised Trials of Antimicrobial Stewardship Interventions
title_sort perspectives of statistician, microbiologist, and clinician stakeholders on the use of microbiological outcomes in randomised trials of antimicrobial stewardship interventions
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215498/
https://www.ncbi.nlm.nih.gov/pubmed/37237788
http://dx.doi.org/10.3390/antibiotics12050885
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