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Presence of Choroidal Caverns in Patients with Posterior and Panuveitis

Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography an...

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Autores principales: Begaj, Tedi, Yuan, Amy, Lains, Ines, Li, Ashley, Han, Samuel, Susarla, Gayatri, Parikh, Ravi, Sobrin, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215513/
https://www.ncbi.nlm.nih.gov/pubmed/37238939
http://dx.doi.org/10.3390/biomedicines11051268
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author Begaj, Tedi
Yuan, Amy
Lains, Ines
Li, Ashley
Han, Samuel
Susarla, Gayatri
Parikh, Ravi
Sobrin, Lucia
author_facet Begaj, Tedi
Yuan, Amy
Lains, Ines
Li, Ashley
Han, Samuel
Susarla, Gayatri
Parikh, Ravi
Sobrin, Lucia
author_sort Begaj, Tedi
collection PubMed
description Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography and indocyanine green angiography for CCs. Clinical and demographic characteristics were extracted from the chart review. Univariate and multivariate mixed-effects logistical models were used to assess the association between clinical and demographic factors and the presence of CCs. One hundred thirty-five patients (251 eyes) met the inclusion criteria: 1 eye had anterior uveitis, 5 had intermediate uveitis, 194 had posterior uveitis, and 51 had panuveitis. The prevalence of CCs was 10%. CCs were only observed in patients with posterior and panuveitis, with a prevalence of 10.8% and 7.8%, respectively. Multifocal choroiditis (MFC) was the type of uveitis where CCs were most frequently observed, with 40% of eyes with MFC having CCs. In addition, male sex (p = 0.024) was associated with CCs. There was no significant difference in the degree of intraocular inflammation or mean subfoveal choroidal thickness between CC+ and CC− eyes. This is the first study to describe CCs in uveitis. Overall, these findings suggest that caverns may be a sequela of structural and/or vascular perturbations in the choroid from uveitis.
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spelling pubmed-102155132023-05-27 Presence of Choroidal Caverns in Patients with Posterior and Panuveitis Begaj, Tedi Yuan, Amy Lains, Ines Li, Ashley Han, Samuel Susarla, Gayatri Parikh, Ravi Sobrin, Lucia Biomedicines Communication Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography and indocyanine green angiography for CCs. Clinical and demographic characteristics were extracted from the chart review. Univariate and multivariate mixed-effects logistical models were used to assess the association between clinical and demographic factors and the presence of CCs. One hundred thirty-five patients (251 eyes) met the inclusion criteria: 1 eye had anterior uveitis, 5 had intermediate uveitis, 194 had posterior uveitis, and 51 had panuveitis. The prevalence of CCs was 10%. CCs were only observed in patients with posterior and panuveitis, with a prevalence of 10.8% and 7.8%, respectively. Multifocal choroiditis (MFC) was the type of uveitis where CCs were most frequently observed, with 40% of eyes with MFC having CCs. In addition, male sex (p = 0.024) was associated with CCs. There was no significant difference in the degree of intraocular inflammation or mean subfoveal choroidal thickness between CC+ and CC− eyes. This is the first study to describe CCs in uveitis. Overall, these findings suggest that caverns may be a sequela of structural and/or vascular perturbations in the choroid from uveitis. MDPI 2023-04-25 /pmc/articles/PMC10215513/ /pubmed/37238939 http://dx.doi.org/10.3390/biomedicines11051268 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Begaj, Tedi
Yuan, Amy
Lains, Ines
Li, Ashley
Han, Samuel
Susarla, Gayatri
Parikh, Ravi
Sobrin, Lucia
Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title_full Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title_fullStr Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title_full_unstemmed Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title_short Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
title_sort presence of choroidal caverns in patients with posterior and panuveitis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215513/
https://www.ncbi.nlm.nih.gov/pubmed/37238939
http://dx.doi.org/10.3390/biomedicines11051268
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