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Presence of Choroidal Caverns in Patients with Posterior and Panuveitis
Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215513/ https://www.ncbi.nlm.nih.gov/pubmed/37238939 http://dx.doi.org/10.3390/biomedicines11051268 |
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author | Begaj, Tedi Yuan, Amy Lains, Ines Li, Ashley Han, Samuel Susarla, Gayatri Parikh, Ravi Sobrin, Lucia |
author_facet | Begaj, Tedi Yuan, Amy Lains, Ines Li, Ashley Han, Samuel Susarla, Gayatri Parikh, Ravi Sobrin, Lucia |
author_sort | Begaj, Tedi |
collection | PubMed |
description | Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography and indocyanine green angiography for CCs. Clinical and demographic characteristics were extracted from the chart review. Univariate and multivariate mixed-effects logistical models were used to assess the association between clinical and demographic factors and the presence of CCs. One hundred thirty-five patients (251 eyes) met the inclusion criteria: 1 eye had anterior uveitis, 5 had intermediate uveitis, 194 had posterior uveitis, and 51 had panuveitis. The prevalence of CCs was 10%. CCs were only observed in patients with posterior and panuveitis, with a prevalence of 10.8% and 7.8%, respectively. Multifocal choroiditis (MFC) was the type of uveitis where CCs were most frequently observed, with 40% of eyes with MFC having CCs. In addition, male sex (p = 0.024) was associated with CCs. There was no significant difference in the degree of intraocular inflammation or mean subfoveal choroidal thickness between CC+ and CC− eyes. This is the first study to describe CCs in uveitis. Overall, these findings suggest that caverns may be a sequela of structural and/or vascular perturbations in the choroid from uveitis. |
format | Online Article Text |
id | pubmed-10215513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102155132023-05-27 Presence of Choroidal Caverns in Patients with Posterior and Panuveitis Begaj, Tedi Yuan, Amy Lains, Ines Li, Ashley Han, Samuel Susarla, Gayatri Parikh, Ravi Sobrin, Lucia Biomedicines Communication Choroidal caverns (CCs) have been described in association with age-related macular degeneration and pachychoroid disease. However, it is unknown if caverns are found in patients with chronic non-infectious uveitis (NIU). Herein, we evaluated patients with NIU who had optical coherence tomography and indocyanine green angiography for CCs. Clinical and demographic characteristics were extracted from the chart review. Univariate and multivariate mixed-effects logistical models were used to assess the association between clinical and demographic factors and the presence of CCs. One hundred thirty-five patients (251 eyes) met the inclusion criteria: 1 eye had anterior uveitis, 5 had intermediate uveitis, 194 had posterior uveitis, and 51 had panuveitis. The prevalence of CCs was 10%. CCs were only observed in patients with posterior and panuveitis, with a prevalence of 10.8% and 7.8%, respectively. Multifocal choroiditis (MFC) was the type of uveitis where CCs were most frequently observed, with 40% of eyes with MFC having CCs. In addition, male sex (p = 0.024) was associated with CCs. There was no significant difference in the degree of intraocular inflammation or mean subfoveal choroidal thickness between CC+ and CC− eyes. This is the first study to describe CCs in uveitis. Overall, these findings suggest that caverns may be a sequela of structural and/or vascular perturbations in the choroid from uveitis. MDPI 2023-04-25 /pmc/articles/PMC10215513/ /pubmed/37238939 http://dx.doi.org/10.3390/biomedicines11051268 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Begaj, Tedi Yuan, Amy Lains, Ines Li, Ashley Han, Samuel Susarla, Gayatri Parikh, Ravi Sobrin, Lucia Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title | Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title_full | Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title_fullStr | Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title_full_unstemmed | Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title_short | Presence of Choroidal Caverns in Patients with Posterior and Panuveitis |
title_sort | presence of choroidal caverns in patients with posterior and panuveitis |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215513/ https://www.ncbi.nlm.nih.gov/pubmed/37238939 http://dx.doi.org/10.3390/biomedicines11051268 |
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