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Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging

This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin, polyphenols, vitamins, carotenoids, flavonoids, etc.), a...

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Detalles Bibliográficos
Autores principales: Mladenov, Mitko, Lubomirov, Lubomir, Grisk, Olaf, Avtanski, Dimiter, Mitrokhin, Vadim, Sazdova, Iliyana, Keremidarska-Markova, Milena, Danailova, Yana, Nikolaev, Georgi, Konakchieva, Rossitza, Gagov, Hristo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215600/
https://www.ncbi.nlm.nih.gov/pubmed/37237992
http://dx.doi.org/10.3390/antiox12051126
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author Mladenov, Mitko
Lubomirov, Lubomir
Grisk, Olaf
Avtanski, Dimiter
Mitrokhin, Vadim
Sazdova, Iliyana
Keremidarska-Markova, Milena
Danailova, Yana
Nikolaev, Georgi
Konakchieva, Rossitza
Gagov, Hristo
author_facet Mladenov, Mitko
Lubomirov, Lubomir
Grisk, Olaf
Avtanski, Dimiter
Mitrokhin, Vadim
Sazdova, Iliyana
Keremidarska-Markova, Milena
Danailova, Yana
Nikolaev, Georgi
Konakchieva, Rossitza
Gagov, Hristo
author_sort Mladenov, Mitko
collection PubMed
description This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin, polyphenols, vitamins, carotenoids, flavonoids, etc.), and the role of the hormones irisin and melatonin in the redox homeostasis of animal and human cells. The correlations between the deviation from optimal redox conditions and inflammation, allergic, aging and autoimmune responses are discussed. Special attention is given to the vascular system, kidney, liver and brain oxidative stress processes. The role of hydrogen peroxide as an intracellular and paracrine signal molecule is also reviewed. The cyanotoxins β-N-methylamino-l-alanine (BMAA), cylindrospermopsin, microcystins and nodularins are introduced as potentially dangerous food and environment pro-oxidants.
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spelling pubmed-102156002023-05-27 Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging Mladenov, Mitko Lubomirov, Lubomir Grisk, Olaf Avtanski, Dimiter Mitrokhin, Vadim Sazdova, Iliyana Keremidarska-Markova, Milena Danailova, Yana Nikolaev, Georgi Konakchieva, Rossitza Gagov, Hristo Antioxidants (Basel) Review This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin, polyphenols, vitamins, carotenoids, flavonoids, etc.), and the role of the hormones irisin and melatonin in the redox homeostasis of animal and human cells. The correlations between the deviation from optimal redox conditions and inflammation, allergic, aging and autoimmune responses are discussed. Special attention is given to the vascular system, kidney, liver and brain oxidative stress processes. The role of hydrogen peroxide as an intracellular and paracrine signal molecule is also reviewed. The cyanotoxins β-N-methylamino-l-alanine (BMAA), cylindrospermopsin, microcystins and nodularins are introduced as potentially dangerous food and environment pro-oxidants. MDPI 2023-05-19 /pmc/articles/PMC10215600/ /pubmed/37237992 http://dx.doi.org/10.3390/antiox12051126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mladenov, Mitko
Lubomirov, Lubomir
Grisk, Olaf
Avtanski, Dimiter
Mitrokhin, Vadim
Sazdova, Iliyana
Keremidarska-Markova, Milena
Danailova, Yana
Nikolaev, Georgi
Konakchieva, Rossitza
Gagov, Hristo
Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title_full Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title_fullStr Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title_full_unstemmed Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title_short Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
title_sort oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215600/
https://www.ncbi.nlm.nih.gov/pubmed/37237992
http://dx.doi.org/10.3390/antiox12051126
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