Cargando…

Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy

Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells’ characteristics such as their angiogenic ability, anti-inflammatory, par...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Seok Gi, George, Nimisha Pradeep, Hwang, Ji Su, Park, Seokho, Kim, Myeong Ok, Lee, Soo Hwan, Lee, Gwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215669/
https://www.ncbi.nlm.nih.gov/pubmed/37237691
http://dx.doi.org/10.3390/bioengineering10050621
_version_ 1785048118519136256
author Kim, Seok Gi
George, Nimisha Pradeep
Hwang, Ji Su
Park, Seokho
Kim, Myeong Ok
Lee, Soo Hwan
Lee, Gwang
author_facet Kim, Seok Gi
George, Nimisha Pradeep
Hwang, Ji Su
Park, Seokho
Kim, Myeong Ok
Lee, Soo Hwan
Lee, Gwang
author_sort Kim, Seok Gi
collection PubMed
description Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells’ characteristics such as their angiogenic ability, anti-inflammatory, paracrine, and anti-apoptotic effects, and homing ability to the damaged brain region. Human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) are attractive NDD therapeutic agents owing to their widespread availability, easy attainability and in vitro manipulation and the lack of ethical issues. Ex vivo hBM-MSC expansion before transplantation is essential because of the low cell numbers in bone marrow aspirates. However, hBM-MSC quality decreases over time after detachment from culture dishes, and the ability of hBM-MSCs to differentiate after detachment from culture dishes remains poorly understood. Conventional analysis of hBM-MSCs characteristics before transplantation into the brain has several limitations. However, omics analyses provide more comprehensive molecular profiling of multifactorial biological systems. Omics and machine learning approaches can handle big data and provide more detailed characterization of hBM-MSCs. Here, we provide a brief review on the application of hBM-MSCs in the treatment of NDDs and an overview of integrated omics analysis of the quality and differentiation ability of hBM-MSCs detached from culture dishes for successful stem cell therapy.
format Online
Article
Text
id pubmed-10215669
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102156692023-05-27 Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy Kim, Seok Gi George, Nimisha Pradeep Hwang, Ji Su Park, Seokho Kim, Myeong Ok Lee, Soo Hwan Lee, Gwang Bioengineering (Basel) Review Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells’ characteristics such as their angiogenic ability, anti-inflammatory, paracrine, and anti-apoptotic effects, and homing ability to the damaged brain region. Human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) are attractive NDD therapeutic agents owing to their widespread availability, easy attainability and in vitro manipulation and the lack of ethical issues. Ex vivo hBM-MSC expansion before transplantation is essential because of the low cell numbers in bone marrow aspirates. However, hBM-MSC quality decreases over time after detachment from culture dishes, and the ability of hBM-MSCs to differentiate after detachment from culture dishes remains poorly understood. Conventional analysis of hBM-MSCs characteristics before transplantation into the brain has several limitations. However, omics analyses provide more comprehensive molecular profiling of multifactorial biological systems. Omics and machine learning approaches can handle big data and provide more detailed characterization of hBM-MSCs. Here, we provide a brief review on the application of hBM-MSCs in the treatment of NDDs and an overview of integrated omics analysis of the quality and differentiation ability of hBM-MSCs detached from culture dishes for successful stem cell therapy. MDPI 2023-05-22 /pmc/articles/PMC10215669/ /pubmed/37237691 http://dx.doi.org/10.3390/bioengineering10050621 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Seok Gi
George, Nimisha Pradeep
Hwang, Ji Su
Park, Seokho
Kim, Myeong Ok
Lee, Soo Hwan
Lee, Gwang
Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title_full Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title_fullStr Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title_full_unstemmed Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title_short Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
title_sort human bone marrow-derived mesenchymal stem cell applications in neurodegenerative disease treatment and integrated omics analysis for successful stem cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215669/
https://www.ncbi.nlm.nih.gov/pubmed/37237691
http://dx.doi.org/10.3390/bioengineering10050621
work_keys_str_mv AT kimseokgi humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT georgenimishapradeep humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT hwangjisu humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT parkseokho humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT kimmyeongok humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT leesoohwan humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy
AT leegwang humanbonemarrowderivedmesenchymalstemcellapplicationsinneurodegenerativediseasetreatmentandintegratedomicsanalysisforsuccessfulstemcelltherapy