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Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structure...

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Autores principales: Kaur, Rajwinder, Kaur, Kirandeep, Alyami, Mohammad H., Lang, Damanpreet Kaur, Saini, Balraj, Bayan, Mohammad F., Chandrasekaran, Balakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215692/
https://www.ncbi.nlm.nih.gov/pubmed/37237812
http://dx.doi.org/10.3390/antibiotics12050909
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author Kaur, Rajwinder
Kaur, Kirandeep
Alyami, Mohammad H.
Lang, Damanpreet Kaur
Saini, Balraj
Bayan, Mohammad F.
Chandrasekaran, Balakumar
author_facet Kaur, Rajwinder
Kaur, Kirandeep
Alyami, Mohammad H.
Lang, Damanpreet Kaur
Saini, Balraj
Bayan, Mohammad F.
Chandrasekaran, Balakumar
author_sort Kaur, Rajwinder
collection PubMed
description The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.
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spelling pubmed-102156922023-05-27 Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives Kaur, Rajwinder Kaur, Kirandeep Alyami, Mohammad H. Lang, Damanpreet Kaur Saini, Balraj Bayan, Mohammad F. Chandrasekaran, Balakumar Antibiotics (Basel) Review The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways. MDPI 2023-05-15 /pmc/articles/PMC10215692/ /pubmed/37237812 http://dx.doi.org/10.3390/antibiotics12050909 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaur, Rajwinder
Kaur, Kirandeep
Alyami, Mohammad H.
Lang, Damanpreet Kaur
Saini, Balraj
Bayan, Mohammad F.
Chandrasekaran, Balakumar
Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title_full Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title_fullStr Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title_full_unstemmed Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title_short Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
title_sort combating microbial infections using metal-based nanoparticles as potential therapeutic alternatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215692/
https://www.ncbi.nlm.nih.gov/pubmed/37237812
http://dx.doi.org/10.3390/antibiotics12050909
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