Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades

Gentamicin causes kidney injury due to its accumulation in proximal tubule epithelial cells via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have potential anti-inflammatory, antioxidant, antimicrobial, and chloride channel-inhibiting effects. The current study investigate...

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Detalles Bibliográficos
Autores principales: Balaha, Mohamed F., Alamer, Ahmed A., Eisa, Alaa A., Aljohani, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215741/
https://www.ncbi.nlm.nih.gov/pubmed/37237729
http://dx.doi.org/10.3390/antibiotics12050826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215741/
https://www.ncbi.nlm.nih.gov/pubmed/37237729
http://dx.doi.org/10.3390/antibiotics12050826

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