Cargando…
Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain
A common neuropsychiatric complication of advanced liver disease, hepatic encephalopathy (HE), impacts the quality of life and length of hospital stays. There is new evidence that gut microbiota plays a significant role in brain development and cerebral homeostasis. Microbiota metabolites are provid...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215854/ https://www.ncbi.nlm.nih.gov/pubmed/37238943 http://dx.doi.org/10.3390/biomedicines11051272 |
_version_ | 1785048162020360192 |
---|---|
author | Shahbazi, Ali Sepehrinezhad, Ali Vahdani, Edris Jamali, Raika Ghasempour, Monireh Massoudian, Shirin Sahab Negah, Sajad Larsen, Fin Stolze |
author_facet | Shahbazi, Ali Sepehrinezhad, Ali Vahdani, Edris Jamali, Raika Ghasempour, Monireh Massoudian, Shirin Sahab Negah, Sajad Larsen, Fin Stolze |
author_sort | Shahbazi, Ali |
collection | PubMed |
description | A common neuropsychiatric complication of advanced liver disease, hepatic encephalopathy (HE), impacts the quality of life and length of hospital stays. There is new evidence that gut microbiota plays a significant role in brain development and cerebral homeostasis. Microbiota metabolites are providing a new avenue of therapeutic options for several neurological-related disorders. For instance, the gut microbiota composition and blood-brain barrier (BBB) integrity are altered in HE in a variety of clinical and experimental studies. Furthermore, probiotics, prebiotics, antibiotics, and fecal microbiota transplantation have been shown to positively affect BBB integrity in disease models that are potentially extendable to HE by targeting gut microbiota. However, the mechanisms that underlie microbiota dysbiosis and its effects on the BBB are still unclear in HE. To this end, the aim of this review was to summarize the clinical and experimental evidence of gut dysbiosis and BBB disruption in HE and a possible mechanism. |
format | Online Article Text |
id | pubmed-10215854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102158542023-05-27 Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain Shahbazi, Ali Sepehrinezhad, Ali Vahdani, Edris Jamali, Raika Ghasempour, Monireh Massoudian, Shirin Sahab Negah, Sajad Larsen, Fin Stolze Biomedicines Review A common neuropsychiatric complication of advanced liver disease, hepatic encephalopathy (HE), impacts the quality of life and length of hospital stays. There is new evidence that gut microbiota plays a significant role in brain development and cerebral homeostasis. Microbiota metabolites are providing a new avenue of therapeutic options for several neurological-related disorders. For instance, the gut microbiota composition and blood-brain barrier (BBB) integrity are altered in HE in a variety of clinical and experimental studies. Furthermore, probiotics, prebiotics, antibiotics, and fecal microbiota transplantation have been shown to positively affect BBB integrity in disease models that are potentially extendable to HE by targeting gut microbiota. However, the mechanisms that underlie microbiota dysbiosis and its effects on the BBB are still unclear in HE. To this end, the aim of this review was to summarize the clinical and experimental evidence of gut dysbiosis and BBB disruption in HE and a possible mechanism. MDPI 2023-04-25 /pmc/articles/PMC10215854/ /pubmed/37238943 http://dx.doi.org/10.3390/biomedicines11051272 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shahbazi, Ali Sepehrinezhad, Ali Vahdani, Edris Jamali, Raika Ghasempour, Monireh Massoudian, Shirin Sahab Negah, Sajad Larsen, Fin Stolze Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title | Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title_full | Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title_fullStr | Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title_full_unstemmed | Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title_short | Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain |
title_sort | gut dysbiosis and blood-brain barrier alteration in hepatic encephalopathy: from gut to brain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215854/ https://www.ncbi.nlm.nih.gov/pubmed/37238943 http://dx.doi.org/10.3390/biomedicines11051272 |
work_keys_str_mv | AT shahbaziali gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT sepehrinezhadali gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT vahdaniedris gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT jamaliraika gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT ghasempourmonireh gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT massoudianshirin gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT sahabnegahsajad gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain AT larsenfinstolze gutdysbiosisandbloodbrainbarrieralterationinhepaticencephalopathyfromguttobrain |