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Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants

The Asian elephant (Elephas maximus) is a flagship species of tropical rainforests, and it has generated much concern. In this case, the gut bacterial communities of captive and wild Asian elephants are particularly noteworthy. We aim to compare the differences in bacterial diversity and antibiotic...

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Autores principales: Cao, Kaixun, Wang, Yepeng, Bai, Xuewei, Wang, Jishan, Zhang, Liting, Tang, Yongjing, Thuku, Rebecca Caroline, Hou, Wei, Mo, Guoxiang, Chen, Fei, Jin, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215966/
https://www.ncbi.nlm.nih.gov/pubmed/37237762
http://dx.doi.org/10.3390/antibiotics12050859
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author Cao, Kaixun
Wang, Yepeng
Bai, Xuewei
Wang, Jishan
Zhang, Liting
Tang, Yongjing
Thuku, Rebecca Caroline
Hou, Wei
Mo, Guoxiang
Chen, Fei
Jin, Lin
author_facet Cao, Kaixun
Wang, Yepeng
Bai, Xuewei
Wang, Jishan
Zhang, Liting
Tang, Yongjing
Thuku, Rebecca Caroline
Hou, Wei
Mo, Guoxiang
Chen, Fei
Jin, Lin
author_sort Cao, Kaixun
collection PubMed
description The Asian elephant (Elephas maximus) is a flagship species of tropical rainforests, and it has generated much concern. In this case, the gut bacterial communities of captive and wild Asian elephants are particularly noteworthy. We aim to compare the differences in bacterial diversity and antibiotic resistance gene (ARG) subtypes in fecal samples of Asian elephants from different habitats, which may affect host health. Analyses reveal that differences in the dominant species of gut bacteria between captive and wild Asian elephants may result in significant differences in ARGs. Network analysis of bacterial communities in captive Asian elephants has identified potentially pathogenic species. Many negative correlations in network analysis suggest that different food sources may lead to differences in bacterial communities and ARGs. Results also indicate that the ARG levels in local captive breeding of Asian elephants are close to those of the wild type. However, we found that local captive elephants carry fewer ARG types than their wild counterparts. This study reveals the profile and relationship between bacterial communities and ARGs in different sources of Asian elephant feces, providing primary data for captive breeding and rescuing wild Asian elephants.
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spelling pubmed-102159662023-05-27 Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants Cao, Kaixun Wang, Yepeng Bai, Xuewei Wang, Jishan Zhang, Liting Tang, Yongjing Thuku, Rebecca Caroline Hou, Wei Mo, Guoxiang Chen, Fei Jin, Lin Antibiotics (Basel) Article The Asian elephant (Elephas maximus) is a flagship species of tropical rainforests, and it has generated much concern. In this case, the gut bacterial communities of captive and wild Asian elephants are particularly noteworthy. We aim to compare the differences in bacterial diversity and antibiotic resistance gene (ARG) subtypes in fecal samples of Asian elephants from different habitats, which may affect host health. Analyses reveal that differences in the dominant species of gut bacteria between captive and wild Asian elephants may result in significant differences in ARGs. Network analysis of bacterial communities in captive Asian elephants has identified potentially pathogenic species. Many negative correlations in network analysis suggest that different food sources may lead to differences in bacterial communities and ARGs. Results also indicate that the ARG levels in local captive breeding of Asian elephants are close to those of the wild type. However, we found that local captive elephants carry fewer ARG types than their wild counterparts. This study reveals the profile and relationship between bacterial communities and ARGs in different sources of Asian elephant feces, providing primary data for captive breeding and rescuing wild Asian elephants. MDPI 2023-05-06 /pmc/articles/PMC10215966/ /pubmed/37237762 http://dx.doi.org/10.3390/antibiotics12050859 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Kaixun
Wang, Yepeng
Bai, Xuewei
Wang, Jishan
Zhang, Liting
Tang, Yongjing
Thuku, Rebecca Caroline
Hou, Wei
Mo, Guoxiang
Chen, Fei
Jin, Lin
Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title_full Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title_fullStr Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title_full_unstemmed Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title_short Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants
title_sort comparison of fecal antimicrobial resistance genes in captive and wild asian elephants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215966/
https://www.ncbi.nlm.nih.gov/pubmed/37237762
http://dx.doi.org/10.3390/antibiotics12050859
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