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IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception

Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the secretion of analgesic substances, culminating...

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Autores principales: Belo, Thiago Caetano Andrade, Santos, Gabriela Xavier, da Silva, Bruno Eduardo Gabriel, Rocha, Bruno Lopes Gonçalves, Abdala, Dennis William, Freire, Larissa Alves Moreira, Rocha, Fernanda Santos, Galdino, Giovane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216064/
https://www.ncbi.nlm.nih.gov/pubmed/37239261
http://dx.doi.org/10.3390/brainsci13050789
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author Belo, Thiago Caetano Andrade
Santos, Gabriela Xavier
da Silva, Bruno Eduardo Gabriel
Rocha, Bruno Lopes Gonçalves
Abdala, Dennis William
Freire, Larissa Alves Moreira
Rocha, Fernanda Santos
Galdino, Giovane
author_facet Belo, Thiago Caetano Andrade
Santos, Gabriela Xavier
da Silva, Bruno Eduardo Gabriel
Rocha, Bruno Lopes Gonçalves
Abdala, Dennis William
Freire, Larissa Alves Moreira
Rocha, Fernanda Santos
Galdino, Giovane
author_sort Belo, Thiago Caetano Andrade
collection PubMed
description Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the secretion of analgesic substances, culminating in the differential expression of genes encoding endogenous opioid peptides, especially β-endorphin. Thus, when β-endorphin binds to the µ-opioid receptor, it generates neuronal hyperpolarization, inhibiting nociceptive stimuli. This review aimed to summarize the recent advances in understanding the mechanism by which IL-10/β-endorphin can reduce pain. For this, databases were searched for articles from their inception up until November 2022. Two independent reviewers extracted the data and assessed the methodological quality of the included studies, and seventeen studies were considered eligible for this review. Several studies have demonstrated the impact of IL-10/β-endorphin in reducing pain, where IL-10 can stimulate GLP-1R, GRP40, and α7nAChR receptors, as well as intracellular signaling pathways, such as STAT3, resulting in increased β-endorphin expression and secretion. In addition, molecules such as gabapentinoids, thalidomide, cynandione A, morroniside, lemairamin, and cinobufagin, as well as non-pharmacological treatments such as electroacupuncture, reduce pain through IL-10 mediated mechanisms, reflecting a microglia-dependent β-endorphin differential increase. This process represents a cornerstone in pain neuroimmunology knowledge, and the results obtained by different studies about the theme are presented in this review.
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spelling pubmed-102160642023-05-27 IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception Belo, Thiago Caetano Andrade Santos, Gabriela Xavier da Silva, Bruno Eduardo Gabriel Rocha, Bruno Lopes Gonçalves Abdala, Dennis William Freire, Larissa Alves Moreira Rocha, Fernanda Santos Galdino, Giovane Brain Sci Review Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the secretion of analgesic substances, culminating in the differential expression of genes encoding endogenous opioid peptides, especially β-endorphin. Thus, when β-endorphin binds to the µ-opioid receptor, it generates neuronal hyperpolarization, inhibiting nociceptive stimuli. This review aimed to summarize the recent advances in understanding the mechanism by which IL-10/β-endorphin can reduce pain. For this, databases were searched for articles from their inception up until November 2022. Two independent reviewers extracted the data and assessed the methodological quality of the included studies, and seventeen studies were considered eligible for this review. Several studies have demonstrated the impact of IL-10/β-endorphin in reducing pain, where IL-10 can stimulate GLP-1R, GRP40, and α7nAChR receptors, as well as intracellular signaling pathways, such as STAT3, resulting in increased β-endorphin expression and secretion. In addition, molecules such as gabapentinoids, thalidomide, cynandione A, morroniside, lemairamin, and cinobufagin, as well as non-pharmacological treatments such as electroacupuncture, reduce pain through IL-10 mediated mechanisms, reflecting a microglia-dependent β-endorphin differential increase. This process represents a cornerstone in pain neuroimmunology knowledge, and the results obtained by different studies about the theme are presented in this review. MDPI 2023-05-12 /pmc/articles/PMC10216064/ /pubmed/37239261 http://dx.doi.org/10.3390/brainsci13050789 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belo, Thiago Caetano Andrade
Santos, Gabriela Xavier
da Silva, Bruno Eduardo Gabriel
Rocha, Bruno Lopes Gonçalves
Abdala, Dennis William
Freire, Larissa Alves Moreira
Rocha, Fernanda Santos
Galdino, Giovane
IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title_full IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title_fullStr IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title_full_unstemmed IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title_short IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
title_sort il-10/β-endorphin-mediated neuroimmune modulation on microglia during antinociception
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216064/
https://www.ncbi.nlm.nih.gov/pubmed/37239261
http://dx.doi.org/10.3390/brainsci13050789
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