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Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury

Reperfusion injury is a very common complication of various indicated therapies such as the re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic shutdown (cardiac arrest, severe trauma, aortic cross-clamping). The treatment and prevention of reperfusion injury has theref...

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Autores principales: Kloka, Jan Andreas, Friedrichson, Benjamin, Wülfroth, Petra, Henning, Rainer, Zacharowski, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216082/
https://www.ncbi.nlm.nih.gov/pubmed/37408180
http://dx.doi.org/10.3390/cells12101345
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author Kloka, Jan Andreas
Friedrichson, Benjamin
Wülfroth, Petra
Henning, Rainer
Zacharowski, Kai
author_facet Kloka, Jan Andreas
Friedrichson, Benjamin
Wülfroth, Petra
Henning, Rainer
Zacharowski, Kai
author_sort Kloka, Jan Andreas
collection PubMed
description Reperfusion injury is a very common complication of various indicated therapies such as the re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic shutdown (cardiac arrest, severe trauma, aortic cross-clamping). The treatment and prevention of reperfusion injury has therefore been a topic of immense interest in terms of mechanistic understanding, the exploration of interventions in animal models and in the clinical setting in major prospective studies. While a wealth of encouraging results has been obtained in the lab, the translation into clinical success has met with mixed outcomes at best. Considering the still very high medical need, progress continues to be urgently needed. Multi-target approaches rationally linking interference with pathophysiological pathways as well as a renewed focus on aspects of microvascular dysfunction, especially on the role of microvascular leakage, are likely to provide new insights.
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spelling pubmed-102160822023-05-27 Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury Kloka, Jan Andreas Friedrichson, Benjamin Wülfroth, Petra Henning, Rainer Zacharowski, Kai Cells Review Reperfusion injury is a very common complication of various indicated therapies such as the re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic shutdown (cardiac arrest, severe trauma, aortic cross-clamping). The treatment and prevention of reperfusion injury has therefore been a topic of immense interest in terms of mechanistic understanding, the exploration of interventions in animal models and in the clinical setting in major prospective studies. While a wealth of encouraging results has been obtained in the lab, the translation into clinical success has met with mixed outcomes at best. Considering the still very high medical need, progress continues to be urgently needed. Multi-target approaches rationally linking interference with pathophysiological pathways as well as a renewed focus on aspects of microvascular dysfunction, especially on the role of microvascular leakage, are likely to provide new insights. MDPI 2023-05-09 /pmc/articles/PMC10216082/ /pubmed/37408180 http://dx.doi.org/10.3390/cells12101345 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kloka, Jan Andreas
Friedrichson, Benjamin
Wülfroth, Petra
Henning, Rainer
Zacharowski, Kai
Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title_full Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title_fullStr Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title_full_unstemmed Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title_short Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury
title_sort microvascular leakage as therapeutic target for ischemia and reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216082/
https://www.ncbi.nlm.nih.gov/pubmed/37408180
http://dx.doi.org/10.3390/cells12101345
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