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The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies

Inflammation-induced coagulopathy is a common complication associated with coronavirus disease 2019 (COVID-19). We aim to evaluate the association of NETosis and complement markers with each other as well as their association with thrombogenicity and disease severity in COVID-19. The study included...

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Autores principales: Ghanbari, Emily Parissa, Jakobs, Kai, Puccini, Marianna, Reinshagen, Leander, Friebel, Julian, Haghikia, Arash, Kränkel, Nicolle, Landmesser, Ulf, Rauch-Kröhnert, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216097/
https://www.ncbi.nlm.nih.gov/pubmed/37239041
http://dx.doi.org/10.3390/biomedicines11051371
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author Ghanbari, Emily Parissa
Jakobs, Kai
Puccini, Marianna
Reinshagen, Leander
Friebel, Julian
Haghikia, Arash
Kränkel, Nicolle
Landmesser, Ulf
Rauch-Kröhnert, Ursula
author_facet Ghanbari, Emily Parissa
Jakobs, Kai
Puccini, Marianna
Reinshagen, Leander
Friebel, Julian
Haghikia, Arash
Kränkel, Nicolle
Landmesser, Ulf
Rauch-Kröhnert, Ursula
author_sort Ghanbari, Emily Parissa
collection PubMed
description Inflammation-induced coagulopathy is a common complication associated with coronavirus disease 2019 (COVID-19). We aim to evaluate the association of NETosis and complement markers with each other as well as their association with thrombogenicity and disease severity in COVID-19. The study included hospitalized patients with an acute respiratory infection: patients with SARS-CoV2 infection (COVpos, n = 47) or either pneumonia or infection-triggered acute exacerbated COPD (COVneg, n = 36). Our results show that NETosis, coagulation, and platelets, as well as complement markers, were significantly increased in COVpos patients, especially in severely ill COVpos patients. NETosis marker MPO/DNA complexes correlated with coagulation, platelet, and complement markers only in COVpos. Severely ill COVpos patients showed an association between complement C3 and SOFA (R = 0.48; p ≤ 0.028), C5 and SOFA (R = 0.46; p ≤ 0.038), and C5b-9 and SOFA (R = 0.44; p ≤ 0.046). This study provides further evidence that NETosis and the complement system are key players in COVID-19 inflammation and clinical severity. Unlike previous studies that found NETosis and complement markers to be elevated in COVID-19 patients compared to healthy controls, our findings show that this characteristic distinguishes COVID-19 from other pulmonary infectious diseases. Based on our results, we propose that COVID-19 patients at high risk for immunothrombosis could be identified via elevated complement markers such as C5.
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spelling pubmed-102160972023-05-27 The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies Ghanbari, Emily Parissa Jakobs, Kai Puccini, Marianna Reinshagen, Leander Friebel, Julian Haghikia, Arash Kränkel, Nicolle Landmesser, Ulf Rauch-Kröhnert, Ursula Biomedicines Article Inflammation-induced coagulopathy is a common complication associated with coronavirus disease 2019 (COVID-19). We aim to evaluate the association of NETosis and complement markers with each other as well as their association with thrombogenicity and disease severity in COVID-19. The study included hospitalized patients with an acute respiratory infection: patients with SARS-CoV2 infection (COVpos, n = 47) or either pneumonia or infection-triggered acute exacerbated COPD (COVneg, n = 36). Our results show that NETosis, coagulation, and platelets, as well as complement markers, were significantly increased in COVpos patients, especially in severely ill COVpos patients. NETosis marker MPO/DNA complexes correlated with coagulation, platelet, and complement markers only in COVpos. Severely ill COVpos patients showed an association between complement C3 and SOFA (R = 0.48; p ≤ 0.028), C5 and SOFA (R = 0.46; p ≤ 0.038), and C5b-9 and SOFA (R = 0.44; p ≤ 0.046). This study provides further evidence that NETosis and the complement system are key players in COVID-19 inflammation and clinical severity. Unlike previous studies that found NETosis and complement markers to be elevated in COVID-19 patients compared to healthy controls, our findings show that this characteristic distinguishes COVID-19 from other pulmonary infectious diseases. Based on our results, we propose that COVID-19 patients at high risk for immunothrombosis could be identified via elevated complement markers such as C5. MDPI 2023-05-05 /pmc/articles/PMC10216097/ /pubmed/37239041 http://dx.doi.org/10.3390/biomedicines11051371 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghanbari, Emily Parissa
Jakobs, Kai
Puccini, Marianna
Reinshagen, Leander
Friebel, Julian
Haghikia, Arash
Kränkel, Nicolle
Landmesser, Ulf
Rauch-Kröhnert, Ursula
The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title_full The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title_fullStr The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title_full_unstemmed The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title_short The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies
title_sort role of netosis and complement activation in covid-19-associated coagulopathies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216097/
https://www.ncbi.nlm.nih.gov/pubmed/37239041
http://dx.doi.org/10.3390/biomedicines11051371
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