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Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area

This study aimed to analyze solute carrier family 27 (SLC27) in glioblastoma tumors. The investigation of these proteins will provide insight into how and to what extent fatty acids are taken up from the blood in glioblastoma tumors, as well as the subsequent fate of the up-taken fatty acids. Tumor...

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Autores principales: Korbecki, Jan, Kojder, Klaudyna, Jeżewski, Dariusz, Simińska, Donata, Tomasiak, Patrycja, Tarnowski, Maciej, Chlubek, Dariusz, Baranowska-Bosiacka, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216168/
https://www.ncbi.nlm.nih.gov/pubmed/37239243
http://dx.doi.org/10.3390/brainsci13050771
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author Korbecki, Jan
Kojder, Klaudyna
Jeżewski, Dariusz
Simińska, Donata
Tomasiak, Patrycja
Tarnowski, Maciej
Chlubek, Dariusz
Baranowska-Bosiacka, Irena
author_facet Korbecki, Jan
Kojder, Klaudyna
Jeżewski, Dariusz
Simińska, Donata
Tomasiak, Patrycja
Tarnowski, Maciej
Chlubek, Dariusz
Baranowska-Bosiacka, Irena
author_sort Korbecki, Jan
collection PubMed
description This study aimed to analyze solute carrier family 27 (SLC27) in glioblastoma tumors. The investigation of these proteins will provide insight into how and to what extent fatty acids are taken up from the blood in glioblastoma tumors, as well as the subsequent fate of the up-taken fatty acids. Tumor samples were collected from a total of 28 patients and analyzed using quantitative real-time polymerase chain reaction (qRT–PCR). The study also sought to explore the relationship between SLC27 expression and patient characteristics (age, height, weight, body mass index (BMI), and smoking history), as well as the expression levels of enzymes responsible for fatty acid synthesis. The expression of SLC27A4 and SLC27A6 was lower in glioblastoma tumors compared to the peritumoral area. Men had a lower expression of SLC27A5. Notably, a positive correlation was observed between the expression of SLC27A4, SLC27A5, and SLC27A6 and smoking history in women, whereas men exhibited a negative correlation between these SLC27s and BMI. The expression of SLC27A1 and SLC27A3 was positively correlated with the expression of ELOVL6. In comparison to healthy brain tissue, glioblastoma tumors take up fewer fatty acids. The metabolism of fatty acids in glioblastoma is dependent on factors such as obesity and smoking.
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spelling pubmed-102161682023-05-27 Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area Korbecki, Jan Kojder, Klaudyna Jeżewski, Dariusz Simińska, Donata Tomasiak, Patrycja Tarnowski, Maciej Chlubek, Dariusz Baranowska-Bosiacka, Irena Brain Sci Article This study aimed to analyze solute carrier family 27 (SLC27) in glioblastoma tumors. The investigation of these proteins will provide insight into how and to what extent fatty acids are taken up from the blood in glioblastoma tumors, as well as the subsequent fate of the up-taken fatty acids. Tumor samples were collected from a total of 28 patients and analyzed using quantitative real-time polymerase chain reaction (qRT–PCR). The study also sought to explore the relationship between SLC27 expression and patient characteristics (age, height, weight, body mass index (BMI), and smoking history), as well as the expression levels of enzymes responsible for fatty acid synthesis. The expression of SLC27A4 and SLC27A6 was lower in glioblastoma tumors compared to the peritumoral area. Men had a lower expression of SLC27A5. Notably, a positive correlation was observed between the expression of SLC27A4, SLC27A5, and SLC27A6 and smoking history in women, whereas men exhibited a negative correlation between these SLC27s and BMI. The expression of SLC27A1 and SLC27A3 was positively correlated with the expression of ELOVL6. In comparison to healthy brain tissue, glioblastoma tumors take up fewer fatty acids. The metabolism of fatty acids in glioblastoma is dependent on factors such as obesity and smoking. MDPI 2023-05-07 /pmc/articles/PMC10216168/ /pubmed/37239243 http://dx.doi.org/10.3390/brainsci13050771 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korbecki, Jan
Kojder, Klaudyna
Jeżewski, Dariusz
Simińska, Donata
Tomasiak, Patrycja
Tarnowski, Maciej
Chlubek, Dariusz
Baranowska-Bosiacka, Irena
Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title_full Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title_fullStr Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title_full_unstemmed Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title_short Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area
title_sort reduced expression of very-long-chain acyl-coa synthetases slc27a4 and slc27a6 in the glioblastoma tumor compared to the peritumoral area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216168/
https://www.ncbi.nlm.nih.gov/pubmed/37239243
http://dx.doi.org/10.3390/brainsci13050771
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