9-O Acetylated Gangliosides in Health and Disease

Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of mo...

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Detalles Bibliográficos
Autores principales: Herrera-Marcos, Luis Vicente, Sahali, Dil, Ollero, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216186/
https://www.ncbi.nlm.nih.gov/pubmed/37238697
http://dx.doi.org/10.3390/biom13050827
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author Herrera-Marcos, Luis Vicente
Sahali, Dil
Ollero, Mario
author_facet Herrera-Marcos, Luis Vicente
Sahali, Dil
Ollero, Mario
author_sort Herrera-Marcos, Luis Vicente
collection PubMed
description Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents the state of the art on 9-O acetylated gangliosides and their link to cellular disorders.
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spelling pubmed-102161862023-05-27 9-O Acetylated Gangliosides in Health and Disease Herrera-Marcos, Luis Vicente Sahali, Dil Ollero, Mario Biomolecules Review Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents the state of the art on 9-O acetylated gangliosides and their link to cellular disorders. MDPI 2023-05-12 /pmc/articles/PMC10216186/ /pubmed/37238697 http://dx.doi.org/10.3390/biom13050827 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herrera-Marcos, Luis Vicente
Sahali, Dil
Ollero, Mario
9-O Acetylated Gangliosides in Health and Disease
title 9-O Acetylated Gangliosides in Health and Disease
title_full 9-O Acetylated Gangliosides in Health and Disease
title_fullStr 9-O Acetylated Gangliosides in Health and Disease
title_full_unstemmed 9-O Acetylated Gangliosides in Health and Disease
title_short 9-O Acetylated Gangliosides in Health and Disease
title_sort 9-o acetylated gangliosides in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216186/
https://www.ncbi.nlm.nih.gov/pubmed/37238697
http://dx.doi.org/10.3390/biom13050827
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