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A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124

(1) Background: A premature termination codon (PTC) can be induced by a type of point mutation known as a nonsense mutation, which occurs within the coding region. Approximately 3.8% of human cancer patients have nonsense mutations of p53. However, the non-aminoglycoside drug PTC124 has shown potent...

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Detalles Bibliográficos
Autores principales:	Chen, Chia-Chi, Liao, Ruo-Yu, Yeh, Fang-Yu, Lin, Yu-Rou, Wu, Tze-You, Pastor, Alexa Escobar, Zul, Danny Danilo, Hsu, Yun-Chien, Wu, Kuan-Yo, Liu, Ke-Fang, Kannagi, Reiji, Chen, Jang-Yi, Cai, Bi-He
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Technical Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216193/ https://www.ncbi.nlm.nih.gov/pubmed/37238980 http://dx.doi.org/10.3390/biomedicines11051310

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