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Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis

The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis, remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors...

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Autores principales: Danila, Edvardas, Aleksonienė, Regina, Besusparis, Justinas, Gruslys, Vygantas, Jurgauskienė, Laimutė, Laurinavičienė, Aida, Laurinavičius, Arvydas, Mainelis, Antanas, Zablockis, Rolandas, Zeleckienė, Ingrida, Žurauskas, Edvardas, Malickaitė, Radvilė
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216233/
https://www.ncbi.nlm.nih.gov/pubmed/37239108
http://dx.doi.org/10.3390/biomedicines11051437
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author Danila, Edvardas
Aleksonienė, Regina
Besusparis, Justinas
Gruslys, Vygantas
Jurgauskienė, Laimutė
Laurinavičienė, Aida
Laurinavičius, Arvydas
Mainelis, Antanas
Zablockis, Rolandas
Zeleckienė, Ingrida
Žurauskas, Edvardas
Malickaitė, Radvilė
author_facet Danila, Edvardas
Aleksonienė, Regina
Besusparis, Justinas
Gruslys, Vygantas
Jurgauskienė, Laimutė
Laurinavičienė, Aida
Laurinavičius, Arvydas
Mainelis, Antanas
Zablockis, Rolandas
Zeleckienė, Ingrida
Žurauskas, Edvardas
Malickaitė, Radvilė
author_sort Danila, Edvardas
collection PubMed
description The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis, remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors for pulmonary sarcoidosis with a special focus on cellular immune inflammation markers. A 2-year follow-up of the study population after the initial prospective and simultaneous analysis of lymphocyte activation markers expression in the blood, as well as bronchoalveolar lavage fluid (BALF) and lung biopsy tissue of patients with newly diagnosed pulmonary sarcoidosis, was performed. We found that some blood and BAL fluid immunological markers and lung computed tomography (CT) patterns have been associated with a different course of sarcoidosis. We revealed five markers that had a significant negative association with the course of sarcoidosis (worsening pulmonary function tests and/or the chest CT changes)—blood CD4+CD31+ and CD4+CD44+ T lymphocytes, BALF CD8+CD31+ and CD8+CD103+ T lymphocytes and a number of lung nodules on chest CT at the time of the diagnosis. Cut-off values, sensitivity, specificity and odds ratio for predictors of sarcoidosis progression were calculated. These markers may be reasonable predictors of sarcoidosis progression.
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spelling pubmed-102162332023-05-27 Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis Danila, Edvardas Aleksonienė, Regina Besusparis, Justinas Gruslys, Vygantas Jurgauskienė, Laimutė Laurinavičienė, Aida Laurinavičius, Arvydas Mainelis, Antanas Zablockis, Rolandas Zeleckienė, Ingrida Žurauskas, Edvardas Malickaitė, Radvilė Biomedicines Article The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis, remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors for pulmonary sarcoidosis with a special focus on cellular immune inflammation markers. A 2-year follow-up of the study population after the initial prospective and simultaneous analysis of lymphocyte activation markers expression in the blood, as well as bronchoalveolar lavage fluid (BALF) and lung biopsy tissue of patients with newly diagnosed pulmonary sarcoidosis, was performed. We found that some blood and BAL fluid immunological markers and lung computed tomography (CT) patterns have been associated with a different course of sarcoidosis. We revealed five markers that had a significant negative association with the course of sarcoidosis (worsening pulmonary function tests and/or the chest CT changes)—blood CD4+CD31+ and CD4+CD44+ T lymphocytes, BALF CD8+CD31+ and CD8+CD103+ T lymphocytes and a number of lung nodules on chest CT at the time of the diagnosis. Cut-off values, sensitivity, specificity and odds ratio for predictors of sarcoidosis progression were calculated. These markers may be reasonable predictors of sarcoidosis progression. MDPI 2023-05-13 /pmc/articles/PMC10216233/ /pubmed/37239108 http://dx.doi.org/10.3390/biomedicines11051437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danila, Edvardas
Aleksonienė, Regina
Besusparis, Justinas
Gruslys, Vygantas
Jurgauskienė, Laimutė
Laurinavičienė, Aida
Laurinavičius, Arvydas
Mainelis, Antanas
Zablockis, Rolandas
Zeleckienė, Ingrida
Žurauskas, Edvardas
Malickaitė, Radvilė
Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title_full Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title_fullStr Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title_full_unstemmed Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title_short Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis
title_sort lymphocyte subsets and pulmonary nodules to predict the progression of sarcoidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216233/
https://www.ncbi.nlm.nih.gov/pubmed/37239108
http://dx.doi.org/10.3390/biomedicines11051437
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