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Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective
Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). However, several aspects of the stimulation have not been completely understood, and realistic computati...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216237/ https://www.ncbi.nlm.nih.gov/pubmed/37238953 http://dx.doi.org/10.3390/biomedicines11051283 |
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author | Guidetti, Matteo Giannoni-Luza, Stefano Bocci, Tommaso Pacheco-Barrios, Kevin Bianchi, Anna Maria Parazzini, Marta Ionta, Silvio Ferrucci, Roberta Maiorana, Natale Vincenzo Verde, Federico Ticozzi, Nicola Silani, Vincenzo Priori, Alberto |
author_facet | Guidetti, Matteo Giannoni-Luza, Stefano Bocci, Tommaso Pacheco-Barrios, Kevin Bianchi, Anna Maria Parazzini, Marta Ionta, Silvio Ferrucci, Roberta Maiorana, Natale Vincenzo Verde, Federico Ticozzi, Nicola Silani, Vincenzo Priori, Alberto |
author_sort | Guidetti, Matteo |
collection | PubMed |
description | Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). However, several aspects of the stimulation have not been completely understood, and realistic computational models based on MRI are the gold standard to predict the interaction between tsDCS-induced electric fields and anatomy. Here, we review the electric fields distribution in the SC during tsDCS as predicted by MRI-based realistic models, compare such knowledge with clinical findings, and define the role of computational knowledge in optimizing tsDCS protocols. tsDCS-induced electric fields are predicted to be safe and induce both transient and neuroplastic changes. This could support the possibility to explore new clinical applications, such as spinal cord injury. For the most applied protocol (2–3 mA for 20–30 min, active electrode over T10–T12 and the reference on the right shoulder), similar electric field intensities are generated in both ventral and dorsal horns of the SC at the same height. This was confirmed by human studies, in which both motor and sensitive effects were found. Lastly, electric fields are strongly dependent on anatomy and electrodes’ placement. Regardless of the montage, inter-individual hotspots of higher values of electric fields were predicted, which could change when the subjects move from a position to another (e.g., from the supine to the lateral position). These characteristics underlines the need for individualized and patient-tailored MRI-based computational models to optimize the stimulation protocol. A detailed modeling approach of the electric field distribution might contribute to optimizing stimulation protocols, tailoring electrodes’ configuration, intensities, and duration to the clinical outcome. |
format | Online Article Text |
id | pubmed-10216237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102162372023-05-27 Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective Guidetti, Matteo Giannoni-Luza, Stefano Bocci, Tommaso Pacheco-Barrios, Kevin Bianchi, Anna Maria Parazzini, Marta Ionta, Silvio Ferrucci, Roberta Maiorana, Natale Vincenzo Verde, Federico Ticozzi, Nicola Silani, Vincenzo Priori, Alberto Biomedicines Review Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). However, several aspects of the stimulation have not been completely understood, and realistic computational models based on MRI are the gold standard to predict the interaction between tsDCS-induced electric fields and anatomy. Here, we review the electric fields distribution in the SC during tsDCS as predicted by MRI-based realistic models, compare such knowledge with clinical findings, and define the role of computational knowledge in optimizing tsDCS protocols. tsDCS-induced electric fields are predicted to be safe and induce both transient and neuroplastic changes. This could support the possibility to explore new clinical applications, such as spinal cord injury. For the most applied protocol (2–3 mA for 20–30 min, active electrode over T10–T12 and the reference on the right shoulder), similar electric field intensities are generated in both ventral and dorsal horns of the SC at the same height. This was confirmed by human studies, in which both motor and sensitive effects were found. Lastly, electric fields are strongly dependent on anatomy and electrodes’ placement. Regardless of the montage, inter-individual hotspots of higher values of electric fields were predicted, which could change when the subjects move from a position to another (e.g., from the supine to the lateral position). These characteristics underlines the need for individualized and patient-tailored MRI-based computational models to optimize the stimulation protocol. A detailed modeling approach of the electric field distribution might contribute to optimizing stimulation protocols, tailoring electrodes’ configuration, intensities, and duration to the clinical outcome. MDPI 2023-04-26 /pmc/articles/PMC10216237/ /pubmed/37238953 http://dx.doi.org/10.3390/biomedicines11051283 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guidetti, Matteo Giannoni-Luza, Stefano Bocci, Tommaso Pacheco-Barrios, Kevin Bianchi, Anna Maria Parazzini, Marta Ionta, Silvio Ferrucci, Roberta Maiorana, Natale Vincenzo Verde, Federico Ticozzi, Nicola Silani, Vincenzo Priori, Alberto Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title | Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title_full | Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title_fullStr | Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title_full_unstemmed | Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title_short | Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective |
title_sort | modeling electric fields in transcutaneous spinal direct current stimulation: a clinical perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216237/ https://www.ncbi.nlm.nih.gov/pubmed/37238953 http://dx.doi.org/10.3390/biomedicines11051283 |
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