Cargando…
Single Fraction and Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, and Reduced Viability of Merlin-Deficient Schwann Cells
SIMPLE SUMMARY: Vestibular schwannomas are benign tumors of the eighth cranial nerve, caused by mutations in the NF2 gene encoding the tumor suppressor, merlin. A standard treatment for vestibular schwannoma is radiation therapy; however, radiation can cause sudden or progressive hearing loss in pat...
Autores principales: | Dinh, Christine T., Chen, Si, Nourbakhsh, Aida, Padgett, Kyle, Johnson, Perry, Goncalves, Stefania, Bracho, Olena, Bas, Esperanza, Bohorquez, Jorge, Monje, Paula V., Fernandez-Valle, Cristina, Elsayyad, Nagy, Liu, Xuezhong, Welford, Scott M., Telischi, Fred |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216287/ https://www.ncbi.nlm.nih.gov/pubmed/37345155 http://dx.doi.org/10.3390/cancers15102818 |
Ejemplares similares
-
Ponatinib promotes a G(1) cell-cycle arrest of merlin/NF2-deficient human schwann cells
por: Petrilli, Alejandra M, et al.
Publicado: (2017) -
Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis
por: Petrilli, Alejandra M., et al.
Publicado: (2013) -
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
por: Mindos, Thomas, et al.
Publicado: (2017) -
Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival
por: Pestoni, Jeanine C., et al.
Publicado: (2019) -
Merlín /
por: Lawhead, Steve
Publicado: (1996)